We recently showed that myelin basic protein (MBP) is hydrolyzed by 26S proteasome
without ubiquitination. The previously suggested concept of charge‐mediated interaction …

The vast majority of cellular proteins are degraded by the 26S proteasome after their
ubiquitination. Here, we report that the major component of the myelin multilayered …

Myelin basic protein (MBP) represents a candidate autoantigen in multiple sclerosis (MS).
We isolated MBP from normal and MS human white matter and purified six components …

Background Matrix metalloproteinases (MMPs) play a significant role in the fragmentation of
myelin basic protein (MBP) and demyelination leading to autoimmune multiple sclerosis …

The biochemical characterization of antigen degradation is an important basis for a better
understanding of both the immune response and autoimmune diseases mediated by MHC …

The ubiquitin‐proteasome system is the major intracellular molecular machinery for protein
degradation and maintenance of protein homeostasis in most human cells. As ubiquitin …

The degradation of myelin in the CNS is the hallmark of multiple sclerosis. Reduction in the
net positive charge of myelin basic protein (MBP), through deimination, correlates strongly …

Although multiple sclerosis (MS) is thought to be an autoimmune disease, the mechanisms
by which immunodominant epitopes are generated and lymphocytes are activated are not …

In the article by Musse et al. in this issue of PNAS (1), the authors present unique and
compelling physico-chemical data that demonstrate the structural instability of myelin in …

Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin.
MBP has long been studied as a factor in the pathogenesis of the autoimmune …