177Lu-NM600 targeted radionuclide therapy extends survival in syngeneic murine models of triple-negative breast cancer
R Hernandez, JJ Grudzinski… - Journal of Nuclear …, 2020 - Soc Nuclear Med
There is a clinically unmet need for effective treatments for triple-negative breast cancer
(TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate …
(TNBC), as it remains the most aggressive subtype of breast cancer. Herein, we demonstrate …
Preclinical characterization of 86/90Y-NM600 in a variety of murine and human cancer tumor models
We characterize the in vivo biodistribution and tumor selectivity of 86Y-NM600, a theranostic
alkylphosphocholine radiometal chelate with broad tumor selectivity, in a variety of …
alkylphosphocholine radiometal chelate with broad tumor selectivity, in a variety of …
[18F]ML-10 PET imaging fails to assess early response to neoadjuvant chemotherapy in a preclinical model of triple negative breast cancer
E Jouberton, S Schmitt, E Chautard… - EJNMMI research, 2020 - Springer
Purpose Pathological complete response to the neoadjuvant therapy (NAT) for triple
negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early …
negative breast cancer (TNBC) is predictive of prolonged patient survival. Methods for early …
[HTML][HTML] Target engagement of an anti-MT1-MMP antibody for triple-negative breast cancer PET imaging and beta therapy
N Magro, M Oteo, E Romero… - Nuclear Medicine and …, 2024 - Elsevier
Purpose Triple-negative breast cancer (TNBC) is a highly aggressive subtype of breast
cancer that lacks effective diagnostic and therapeutic options. Membrane type 1 matrix …
cancer that lacks effective diagnostic and therapeutic options. Membrane type 1 matrix …
Targeted Radionuclide Therapy in Patient-Derived Xenografts Using 177Lu-EB-RGD
Currently, most patients with non–small cell lung cancer (NSCLC) are diagnosed in
advanced stages with a poor five-year survival rate. Therefore, intensive research aimed at …
advanced stages with a poor five-year survival rate. Therefore, intensive research aimed at …
Adjuvant Auger Electron-Emitting Radioimmunotherapy with [111In]In-DOTA-Panitumumab in a Mouse Model of Local Recurrence and Metastatic Progression of …
VJ Facca, Z Cai, A Ku, CJ Georgiou… - Molecular …, 2023 - ACS Publications
Triple-negative breast cancer (TNBC) has a high risk for recurrence and metastasis. We
studied the effectiveness of Auger electron (AE) radioimmunotherapy (RIT) with …
studied the effectiveness of Auger electron (AE) radioimmunotherapy (RIT) with …
Drug resistance profiling of a new triple negative breast cancer patient-derived xenograft model
MD Matossian, HE Burks, S Elliott, VT Hoang… - BMC cancer, 2019 - Springer
Background Triple-negative breast cancer (TNBC) represents an aggressive subtype with
limited therapeutic options. Experimental preclinical models that recapitulate their tumors of …
limited therapeutic options. Experimental preclinical models that recapitulate their tumors of …
Treatment of triple-negative breast cancer using anti-EGFR–directed radioimmunotherapy combined with radiosensitizing chemotherapy and PARP inhibitor
Triple-negative breast cancer (TNBC) is associated with poor survival. Chemotherapy is the
only standard treatment for TNBC. The prevalence of BRCA1 inactivation in TNBC has …
only standard treatment for TNBC. The prevalence of BRCA1 inactivation in TNBC has …
[HTML][HTML] Bridging the divide: preclinical research discrepancies between triple-negative breast cancer cell lines and patient tumors
A Sulaiman, L Wang - Oncotarget, 2017 - ncbi.nlm.nih.gov
Triple-negative breast cancer (TNBC) is the most refractory subtype of breast cancer and
disproportionately accounts for the majority of breast cancer related deaths. Effective …
disproportionately accounts for the majority of breast cancer related deaths. Effective …
Noninvasive 89Zr-transferrin PET shows improved tumor targeting compared with 18F-FDG PET in MYC-overexpressing human triple-negative breast cancer
KE Henry, TR Dilling, D Abdel-Atti… - Journal of Nuclear …, 2018 - Soc Nuclear Med
The current standard for breast PET imaging is 18F-FDG. The heterogeneity of 18F-FDG
uptake in breast cancer limits its utility, varying greatly among receptor status …
uptake in breast cancer limits its utility, varying greatly among receptor status …
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