Background: Acute myeloid leukemia (AML) is a heterogeneous disease characterized by
abnormal clonal expansion and is the most common form of adult acute leukemia. Though …

Acute myeloid leukemia (AML) is a clonal disorder of hematopoiesis and the most common
form of acute leukemia in adults. Most patients with AML relapse despite intensive …

Background & Aim Chimeric antigen receptor T-cells (CART) for acute myeloid leukemia
(AML) are limited by hematological toxicity due to shared antigens in AML blasts & healthy …

Genome editing via homologous recombination (HR)(gene targeting) in human
hematopoietic stem cells (HSCs) has the power to reveal gene–function relationships and …

CRISPR/Cas gene editing has transformed genetic research and is poised to drive the next
generation of gene therapies targeting hematopoietic stem cells (HSCs). However, the …

OBJECTIVES► Demonstrate that multiplex (MPX) deletion of CD33 and CLL-1 from CD34+
human hematopoietic stem and progenitor cells (hHSPCs) does not impact HSC function► …

CRISPR/Cas gene editing has transformed genetic research and is poised to drive the next
generation of gene therapies targeting hematopoietic stem cells (HSCs). However, the …

Acute myeloid leukemia (AML) is challenging to treat with antigen-specific immunotherapy
due to the lack of leukemia-specific surface antigens that are absent from normal …

We conducted two lines of genome-editing experiments of mouse hematopoietic stem cells
(HSCs) with the clustered regularly interspaced short palindromic repeat (CRISPR) and …

Immunotherapies are precise antigen-specific approaches that revolutionize cancer
treatment. The goal is to specifically target cancer cells while minimizing effects on healthy …