Phase transitions and size scaling of membrane-less organelles
CP Brangwynne - Journal of Cell Biology, 2013 - rupress.org
The coordinated growth of cells and their organelles is a fundamental and poorly
understood problem, with implications for processes ranging from embryonic development …
understood problem, with implications for processes ranging from embryonic development …
Multiple modes of protein–protein interactions promote RNP granule assembly
Eukaryotic cells are known to contain a wide variety of RNA–protein assemblies, collectively
referred to as RNP granules. RNP granules form from a combination of RNA–RNA, protein …
referred to as RNP granules. RNP granules form from a combination of RNA–RNA, protein …
Independent active and thermodynamic processes govern the nucleolus assembly in vivo
H Falahati, E Wieschaus - Proceedings of the National …, 2017 - National Acad Sciences
Membraneless organelles play a central role in the organization of protoplasm by
concentrating macromolecules, which allows efficient cellular processes. Recent studies …
concentrating macromolecules, which allows efficient cellular processes. Recent studies …
Nucleation by rRNA dictates the precision of nucleolus assembly
H Falahati, B Pelham-Webb, S Blythe, E Wieschaus - Current Biology, 2016 - cell.com
Membrane-less organelles are intracellular compartments specialized to carry out specific
cellular functions. There is growing evidence supporting the possibility that such organelles …
cellular functions. There is growing evidence supporting the possibility that such organelles …
Inverse size scaling of the nucleolus by a concentration-dependent phase transition
SC Weber, CP Brangwynne - Current Biology, 2015 - cell.com
Just as organ size typically increases with body size, the size of intracellular structures
changes as cells grow and divide. Indeed, many organelles, such as the nucleus [1, 2] …
changes as cells grow and divide. Indeed, many organelles, such as the nucleus [1, 2] …
Soft active aggregates: mechanics, dynamics and self-assembly of liquid-like intracellular protein bodies
CP Brangwynne - Soft Matter, 2011 - pubs.rsc.org
Intracellular bodies consisting of dynamic aggregates of concentrated proteins and often
RNA are a ubiquitous feature of the cytoplasm and nucleus of living cells. Dozens of different …
RNA are a ubiquitous feature of the cytoplasm and nucleus of living cells. Dozens of different …
Beyond stereospecificity: liquids and mesoscale organization of cytoplasm
AA Hyman, CP Brangwynne - Developmental cell, 2011 - cell.com
The cytoplasm is not a homogenous solution but instead consists of large dynamic
assemblies that arise from transient molecular interactions. Some of these structures have …
assemblies that arise from transient molecular interactions. Some of these structures have …
Endoplasmic reticulum contact sites regulate the dynamics of membraneless organelles
INTRODUCTION The cytoplasm contains an unconventional class of organelles that
concentrate specific factors and resources without a limiting membrane. These …
concentrate specific factors and resources without a limiting membrane. These …
Phase separation in biology; functional organization of a higher order
DM Mitrea, RW Kriwacki - Cell Communication and Signaling, 2016 - Springer
Inside eukaryotic cells, macromolecules are partitioned into membrane-bounded
compartments and, within these, some are further organized into non-membrane-bounded …
compartments and, within these, some are further organized into non-membrane-bounded …
Organelle growth control through limiting pools of cytoplasmic components
NW Goehring, AA Hyman - Current Biology, 2012 - cell.com
The critical importance of controlling the size and number of intracellular organelles has led
to a variety of mechanisms for regulating the formation and growth of cellular structures. In …
to a variety of mechanisms for regulating the formation and growth of cellular structures. In …