Contrasting effects of oral and transdermal routes of estrogen replacement therapy on 24-hour growth hormone (GH) secretion, insulin-like growth factor I, and GH …

AJ WEISSBERGER, KENKY HO… - The Journal of Clinical …, 1991 - academic.oup.com
Estrogen deficiency may account for lower circulating GH and insulin-like growth factor I (IGF-
I) concentrations in the menopause. Since the liver is the major source of circulating IGF-I …

Effects of oral versus transdermal estrogen on the growth hormone/insulin-like growth factor I axis in younger and older postmenopausal women: a clinical research …

MF Bellantoni, J Vittone, AT Campfield… - The Journal of …, 1996 - academic.oup.com
To compare the effects of oral vs. transdermal estrogens on GH secretion and levels of
circulating insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) in younger …

Both oral and transdermal estrogen increase growth hormone release in postmenopausal women--a clinical research center study

KE Friend, ML Hartman, SS Pezzoli… - The Journal of …, 1996 - academic.oup.com
To determine if the mode of 17 beta-estradiol (E2) administration affects growth hormone
(GH) concentrations, eight postmenopausal women were studied under the following …

Effects of progestin-opposed transdermal estrogen administration on growth hormone and insulin-like growth factor-I in postmenopausal women of different ages

MF Bellantoni, SM Harman, DE Cho… - The Journal of …, 1991 - academic.oup.com
Prior studies in women have shown a positive correlation of endogenous estrogen levels
with spontaneous and stimulated GH secretion and basal insulin-like growth factor-I (IGF-I) …

Oral estrogen antagonizes the metabolic actions of growth hormone in growth hormone-deficient women

T Wolthers, DM Hoffman, AG Nugent… - American Journal …, 2001 - journals.physiology.org
We have determined whether oral estrogen reduces the biological effects of growth
hormone (GH) in GH-deficient (GHD) women compared with transdermal estrogen …

Route of estrogen administration helps to determine growth hormone (GH) replacement dose in GH-deficient adults

DM Cook, WH Ludlam, MB Cook - The Journal of Clinical …, 1999 - academic.oup.com
We prospectively studied two groups of GH-deficient patients during GH therapy based upon
exposure of the liver to elevated (oral estrogen) or not elevated (endogenous or …

Effects of different oral oestrogen formulations on insulin‐like growth factor‐I, growth hormone and growth hormone binding protein in post‐menopausal women

JJ Kelly, IA Rajkovic, AJ O'Sullivan… - Clinical …, 1993 - Wiley Online Library
OBJECTIVE Insulin like growth factor‐I (IGF‐I) levels in post‐menopausal women are
reduced by oral administration of the synthetic oestrogen ethinyl oestradiol but increased by …

Regulation of growth hormone and somatomedin-C secretion in postmenopausal women: effect of physiological estrogen replacement

B DAWSON-HUGHES, D STERN… - The Journal of …, 1986 - academic.oup.com
To determine the effects of estrogen deficiency and replacement on GH secretion, we
measured the 22-h GH secretory pattern and response to 1 h of light exercise in 16 normal …

Sex steroid regulation of growth hormone secretion and action

KKY Ho, AJ O'Sullivan, AJ Weissberger… - Hormone Research in …, 1996 - karger.com
Evidence that oestrogen is involved in the regulation of the somatotrophic axis in adult
humans is provided by the observations that mean growth hormone (GH) levels are higher …

Estrogens exert route-and dose-dependent effects on insulin-like growth factor (IGF)-binding protein-3 and the acid-labile subunit of the IGF ternary complex

GYW Kam, KC Leung, RC Baxter… - The Journal of Clinical …, 2000 - academic.oup.com
We have previously shown that exogenous estrogens exert route-dependent effects on
serum GH and insulin-like growth factor I (IGF-I) levels. IGF-I circulates as a ternary complex …