Sézary syndrome (SS) carries a poor prognosis, and infections represent the most frequent
cause of death in SS patients. Toll-like receptors (TLRs) are a family of innate immune …

The cytokine storm includes a clinically heterogeneous set of life-threatening conditions that
are manifested by extremely elevated serum cytokine levels and related symptoms (eg …

Abstract Background. Triggering Toll-like receptors (TLRs) on dendritic cells (DCs) induces
inflammatory cytokine production necessary for T helper type 1 immunity. The present study …

Summary Toll-like receptors (TLRs), which are a family of pattern recognition receptors
(PRRs), are involved critically in the generation and regulation of innate immunity as well as …

Prolonged or repeated stimulation of Toll-like receptor (TLR) 4 leads to hyporesponsiveness
of monocyte-derived macrophages, which seems to be a hallmark of immunosuppression …

Toll like receptors (TLRs) are a family of pattern recognition receptors that play a central role
in pathogen recognition and shaping the innate immune response. While most of the studies …

Toll-like receptor (TLR) agonists are promising adjuvants for immune therapy of cancer, but
their potential efficacy as single or combinatorial agents has yet to be fully evaluated. Here …

Advanced cutaneous T-cell lymphoma (CTCL) is typically associated with a variety of
profound defects of cellular immunity, including depressed dendritic cell numbers and …

The innate immune system deploys a variety of pattern-recognition receptors (PRRs) which
include Toll-like receptors (TLRs), RIG-I-like receptors, NOD-like receptors, and C-type lectin …

Toll-like receptors (TLR) 7 and 9 transduce a cellular signal through the MyD88-dependent
pathway and induce the production of inflammatory mediators against microbial nucleotide …