Recent evidence implicates the insulin-like growth factor (IGF) pathway in development of
Ewing sarcoma, a highly malignant bone and soft-tissue tumor that primarily affects children …

PTEN is the most important negative regulator of the PI3K signaling pathway. In addition to
its canonical, PI3K inhibition-dependent functions, PTEN can also function as a tumor …

Background PTEN loss has been identified in various tumor types and is linked to
unfavorable clinical outcomes. In addition to PTEN mutation, multiple mechanisms …

Germline pathogenic phosphatase and tensin homolog (PTEN) mutations cause PTEN
hamartoma tumor syndrome (PHTS), characterized by various benign and malignant tumors …

Background/Aim: Sarcoma carries a poor prognosis prompting the need for targeted
therapies aimed at deregulated signaling pathways. These include the PI3K/Akt/mTOR …

Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) is a tumor suppressor
that antagonizes the phosphatidylinositol-3-kinase (PI3K)/Akt/mTOR pathway by functioning …

The PTEN (phosphatase and tensin homologue deleted on chromosome 10) tumour
suppressor is a PI (phosphoinositide) 3-phosphatase that can inhibit cellular proliferation …

Soft tissue sarcoma (STS) is a rare malignancy of mesenchymal origin classified into more
than 50 different subtypes with distinct clinical and pathologic features. Despite the poor …

In tumors, somatic mutations of the PTEN suppressor gene are associated with advanced
disease, chemotherapy resistance, and poor survival. PTEN loss of function may occur by …

In this review, we will first briefly describe the diverse molecular mechanisms associated
with PTEN loss of function in cancer. We will then proceed to discuss the molecular …