Background: Advancing structural and functional maturation of stem cell–derived
cardiomyocytes remains a key challenge for applications in disease modeling, drug …

Ischemic heart disease remains one of the most prominent causes of mortalities worldwide
with heart transplantation being the gold-standard treatment option. However, due to the …

Engineering functional human cardiac tissue that mimics the native adult morphological and
functional phenotype has been a long held objective. In the last 5 years, the field of cardiac …

Heart attack remains the leading cause of death in both men and women worldwide. Stem
cell-based therapies, including the use of engineered cardiac tissues, have the potential to …

Engineered cardiac tissues derived from human induced pluripotent stem cells offer unique
opportunities for patient-specific disease modeling, drug discovery and cardiac repair. Since …

The mammalian heart undergoes maturation during postnatal life to meet the increased
functional requirements of an adult. However, the key drivers of this process remain poorly …

Rationale: More than 25 million individuals have heart failure worldwide, with≈ 4000
patients currently awaiting heart transplantation in the United States. Donor organ shortage …

The ability of human pluripotent stem cells to form all cells of the body has provided many
opportunities to study disease and produce cells that can be used for therapy in …

Heart disease is the leading cause of death in the world. Heart tissue engineering holds a
great promise for future heart disease therapy by building personalized heart tissues. Here …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …