Diet supplementation with allicin protects against alcoholic fatty liver disease in mice by improving anti-inflammation and antioxidative functions

S Panyod, WK Wu, CT Ho, KH Lu, CT Liu… - Journal of Agricultural …, 2016 - ACS Publications
This study investigated the liver-protective effects of allicin, an active compound in fresh
garlic, against alcoholic fatty liver disease (AFLD) and liver inflammation. Its effects were …

Allicin modifies the composition and function of the gut microbiota in alcoholic hepatic steatosis mice

S Panyod, WK Wu, KH Lu, CT Liu, YL Chu… - Journal of agricultural …, 2020 - ACS Publications
The intestinal microbiome plays an important role in the pathogenesis of liver diseases.
Alcohol intake induces gut microbiota dysbiosis and alters its function. This study …

[HTML][HTML] Allicin ameliorates glucose and lipid metabolism via modulation of gut microbiota and bile acid profile in diabetic rats

Z Wang, L Ding, J Liu, P Savarin, X Wang… - Journal of Functional …, 2023 - Elsevier
Diabetes mellitus is a widely prevalent chronic disease, and effective treatments for it remain
limited. Allicin has anti-diabetic effect, however, the detailed mechanism has not been well …

Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease

JT Hwang, EJ Shin, MY Chung… - Nutrition Research …, 2018 - synapse.koreamed.org
BACKGROUND/OBJECTIVES Non-alcoholic fatty liver disease (NAFLD) is a leading cause
of chronic liver disease and is closely associated with metabolic syndrome. In the present …

Hepatoprotective effect of allicin on tissue defense system in galactosamine/endotoxin challenged rats

V Vimal, T Devaki - Journal of ethnopharmacology, 2004 - Elsevier
Allicin (diallythiosulfinate) is the main biologically active component of freshly crushed garlic
(Alliaceae Allium sativum Linn.) cloves. It is produced by the interaction of the non-protein …

Allicin, the active component of garlic, prevents immune‐mediated, concanavalin A‐induced hepatic injury in mice

R Bruck, H Aeed, E Brazovsky, T Noor… - Liver …, 2005 - Wiley Online Library
Background/Aim: Allicin, the immunologically active component of garlic, has been found to
affect oxidative stress and immune response in several experimental systems. In the present …

Aloin protects against chronic alcoholic liver injury via attenuating lipid accumulation, oxidative stress and inflammation in mice

Y Cui, Q Ye, H Wang, Y Li, X Xia, W Yao… - Archives of pharmacal …, 2014 - Springer
The present study was designed to investigate the protective effect of aloin against alcoholic
liver disease in a chronic alcohol feeding mouse model. Mice were given alcohol twice a …

Allicin alleviated acrylamide-induced NLRP3 inflammasome activation via oxidative stress and endoplasmic reticulum stress in Kupffer cells and SD rats liver

B Nan, C Yang, L Li, H Ye, H Yan, M Wang… - Food and Chemical …, 2021 - Elsevier
Acrylamide (AA) in heat-processed food leads to widespread concerns due to its
hepatotoxicity. Allicin, a plant-derived antioxidant, possesses a significant protective effect …

Hepatoprotective effect of allicin against acetaminophen‐induced liver injury: Role of inflammasome pathway, apoptosis, and liver regeneration

YA Samra, MF Hamed… - Journal of biochemical …, 2020 - Wiley Online Library
Acetaminophen (APAP) overdose leads to liver injury. NLRP3 inflammasome is a key player
in APAP‐induced inflammation. Also, apoptosis and liver regeneration play an important …

Genistein protects against acetaldehyde-induced oxidative stress and hepatocyte injury in chronic alcohol-fed mice

Q Ding, A Pi, L Hao, T Xu, Q Zhu, L Shu… - Journal of Agricultural …, 2023 - ACS Publications
Alcohol-related liver disease (ALD) is one of the most prevalent forms of liver disease in the
world. Acetaldehyde, an intermediate product of alcohol catabolism, is a cause of liver injury …