[HTML][HTML] N-wasp is essential for the negative regulation of B cell receptor signaling
C Liu, X Bai, J Wu, S Sharma, A Upadhyaya… - PLoS …, 2013 - journals.plos.org
Negative regulation of receptor signaling is essential for controlling cell activation and
differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) …
differentiation. In B-lymphocytes, the down-regulation of B-cell antigen receptor (BCR) …
N-WASP is required for B-cell–mediated autoimmunity in Wiskott-Aldrich syndrome
Abstract Mutations of the Wiskott-Aldrich syndrome gene (WAS) are responsible for Wiskott-
Aldrich syndrome (WAS), a disease characterized by thrombocytopenia, eczema …
Aldrich syndrome (WAS), a disease characterized by thrombocytopenia, eczema …
Wiskott-Aldrich syndrome protein (WASP) and N-WASP are critical for peripheral B-cell development and function
LS Westerberg, C Dahlberg, M Baptista… - Blood, The Journal …, 2012 - ashpublications.org
Abstract The Wiskott-Aldrich syndrome protein (WASP) is a key cytoskeletal regulator of
hematopoietic cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal …
hematopoietic cells. Although WASP-knockout (WKO) mice have aberrant B-cell cytoskeletal …
Deletion of WASp and N-WASp in B cells cripples the germinal center response and results in production of IgM autoantibodies
CIM Dahlberg, ML Torres, SH Petersen… - Journal of …, 2015 - Elsevier
Humoral immunodeficiency caused by mutations in the Wiskott-Aldrich syndrome protein
(WASp) is associated with failure to respond to common pathogens and high frequency of …
(WASp) is associated with failure to respond to common pathogens and high frequency of …
B cell–intrinsic deficiency of the Wiskott-Aldrich syndrome protein (WASp) causes severe abnormalities of the peripheral B-cell compartment in mice
M Recher, SO Burns, MA de la Fuente… - Blood, The Journal …, 2012 - ashpublications.org
Wiskott Aldrich syndrome (WAS) is caused by mutations in the WAS gene that encodes for a
protein (WASp) involved in cytoskeleton organization in hematopoietic cells. Several …
protein (WASp) involved in cytoskeleton organization in hematopoietic cells. Several …
WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity
S Becker-Herman, A Meyer-Bahlburg… - Journal of Experimental …, 2011 - rupress.org
Patients with the immunodeficiency Wiskott-Aldrich syndrome (WAS) frequently develop
systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B …
systemic autoimmunity. Here, we demonstrate that mutation of the WAS gene results in B …
[HTML][HTML] Critical role of WASp in germinal center tolerance through regulation of B cell apoptosis and diversification
M Descatoire, R Fritzen, S Rotman, G Kuntzelman… - Cell Reports, 2022 - cell.com
A main feature of Wiskott-Aldrich syndrome (WAS) is increased susceptibility to
autoimmunity. A key contribution of B cells to development of these complications has been …
autoimmunity. A key contribution of B cells to development of these complications has been …
[HTML][HTML] The lack of WIP binding to actin results in impaired B cell migration and altered humoral immune responses
SJ Keppler, M Burbage, F Gasparrini, L Hartjes… - Cell reports, 2018 - cell.com
Summary Wiskott-Aldrich syndrome protein (WASp) is a main cytoskeletal regulator in B
cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with …
cells. WASp-interacting protein (WIP) binds to and stabilizes WASp but also interacts with …
Altered BCR and TLR signals promote enhanced positive selection of autoreactive transitional B cells in Wiskott-Aldrich syndrome
NS Kolhatkar, A Brahmandam, CD Thouvenel… - Journal of Experimental …, 2015 - rupress.org
Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency disorder frequently
associated with systemic autoimmunity, including autoantibody-mediated cytopenias. WAS …
associated with systemic autoimmunity, including autoantibody-mediated cytopenias. WAS …
[HTML][HTML] Wiskott-Aldrich syndrome protein-deficient mice reveal a role for WASP in T but not B cell activation
SB Snapper, FS Rosen, E Mizoguchi, P Cohen… - Immunity, 1998 - cell.com
Abstract The Wiskott-Aldrich syndrome (WAS) is a human X-linked immunodeficiency
resulting from mutations in a gene (WASP) encoding a cytoplasmic protein implicated in …
resulting from mutations in a gene (WASP) encoding a cytoplasmic protein implicated in …