Measurement and comparison of immune diversity by high-throughput sequencing

SR Quake, J Weinstein, N Jiang, DS Fisher - US Patent 9,234,240, 2016 - Google Patents
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High-throughput immune sequencing

GM Church, F Vigneault, U Laserson… - US Patent …, 2019 - Google Patents
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High-throughput immune sequencing - Google Patents High-throughput immune sequencing …

Measurement and comparison of immune diversity by high-throughput sequencing

SR Quake, J Weinstein, N Jiang, DS Fisher - 2011 - Google Patents
Upon exposure to antigen there can be a positive selection process, where cells expressing
immunological receptors having desired binding properties are expanded, and may …

Quantification of adaptive immune cell genomes in a complex mixture of cells

HS Robins, CS Carlson, MJ Rieder… - US Patent …, 2018 - Google Patents
A relative representation of adaptive immune cells in a biological sample is quantified using
multiplex PCR and sequencing of adaptive immune cells, control genes, and synthetic …

Single cell bar-coding for antibody discovery

F Vigneault, AW Briggs - US Patent 10,119,134, 2018 - Google Patents
Provided herein are methods and composition for immune repertoire sequencing and single
cell barcoding. In some aspects, such methods may comprise steps of:(a) forming a plurality …

Spatial transcriptomics for antigen-receptors

C Engblom, K Thrane, J Mold, J Frisen… - US Patent …, 2023 - Google Patents
US11692218B2 - Spatial transcriptomics for antigen-receptors - Google Patents
US11692218B2 - Spatial transcriptomics for antigen-receptors - Google Patents Spatial …

Methods of single-cell barcoding and sequencing

F Vigneault, AW Briggs - US Patent 10,392,614, 2019 - Google Patents
Provided herein are methods for immune repertoire sequencing and single cell barcoding.
In some aspects, such methods may comprise producing a plurality of cDNAs from a plurality …

Primers for immune repertoire profiling

D Jensen, K Lazaruk, D Prosen, RA Acob… - US Patent …, 2023 - Google Patents
2021-05-13 Assigned to BECTON, DICKINSON AND COMPANY reassignment BECTON,
DICKINSON AND COMPANY ASSIGNMENT OF ASSIGNORS INTEREST (SEE …

Quantification of adaptive immune cell genomes in a complex mixture of cells

HS Robins, RJ Livingston, JH Bielas - US Patent 9,279,159, 2016 - Google Patents
2022-12-22 Assigned to FRED HUTCHINSON CANCER CENTER reassignment FRED
HUTCHINSON CANCER CENTER MERGER AND CHANGE OF NAME (SEE DOCUMENT …

Predicting immunogenicity of T cell epitopes

U Sahin, AD Tadmor, JC Castle, S Boegel… - US Patent …, 2022 - Google Patents
4,897,355 A 5,264,618 A 5,703,055 A 6,251,399 B1 6,472,176 B2 6,500,641 B1 6,586,410
B1 7,303,881 B2 7,462,354 B2 7,790,696 B2 8,140,270 B2 8,217,016 B2 8,349,558 B2 …