Connexin-based channels contribute to metabolic pathways in the oligodendroglial lineage

J Niu, T Li, C Yi, N Huang, A Koulakoff… - Journal of Cell …, 2016 - journals.biologists.com
Oligodendrocyte precursor cells (OPCs) undergo a series of energy-consuming
developmental events; however, the uptake and trafficking pathways for their energy …

Connexin-mediated functional and metabolic coupling between astrocytes and neurons

LC Mayorquin, AV Rodriguez, JJ Sutachan… - Frontiers in molecular …, 2018 - frontiersin.org
The central nervous system (CNS) requires sophisticated regulation of neuronal activity.
This modulation is partly accomplished by non-neuronal cells, characterized by the …

Connexin-dependent neuroglial networking as a new therapeutic target

M Charvériat, CC Naus, L Leybaert, JC Sáez… - Frontiers in Cellular …, 2017 - frontiersin.org
Astrocytes and neurons dynamically interact during physiological processes, and it is now
widely accepted that they are both organized in plastic and tightly regulated networks …

Astroglial metabolic networks sustain hippocampal synaptic transmission

N Rouach, A Koulakoff, V Abudara, K Willecke… - science, 2008 - science.org
Astrocytes provide metabolic substrates to neurons in an activity-dependent manner.
However, the molecular mechanisms involved in this function, as well as its role in synaptic …

Connexin and pannexin-based channels in oligodendrocytes: implications in brain health and disease

S Vejar, JE Oyarzún, MA Retamal, FC Ortiz… - Frontiers in cellular …, 2019 - frontiersin.org
Oligodendrocytes are the myelin forming cells in the central nervous system (CNS). In
addition to this main physiological function, these cells play key roles by providing energy …

Hypothalamic astroglial connexins are required for brain glucose sensing-induced insulin secretion

C Allard, L Carneiro, S Grall, BH Cline… - Journal of Cerebral …, 2014 - journals.sagepub.com
Hypothalamic glucose detection participates in maintaining glycemic balance, food intake,
and thermogenesis. Although hypothalamic neurons are the executive cells involved in …

Inhibition of astrocyte connexin 43 channels facilitates the differentiation of oligodendrocyte precursor cells under hypoxic conditions in vitro

Q Wang, Z Wang, Y Tian, H Zhang, Y Fang… - Journal of Molecular …, 2018 - Springer
Oligodendrocyte precursor cells (OPCs) proliferation and differentiation are essential for
remyelination after white matter injury. Astrocytes could promote oligodendrogenesis after …

A specific GABAergic synapse onto oligodendrocyte precursors does not regulate cortical oligodendrogenesis

M Balia, N Benamer, MC Angulo - Glia, 2017 - Wiley Online Library
In the brain, neurons establish bona fide synapses onto oligodendrocyte precursor cells
(OPCs), but the function of these neuron‐glia synapses remains unresolved. A leading …

[HTML][HTML] Astrocytes and oligodendrocytes in the thalamus jointly maintain synaptic activity by supplying metabolites

C Philippot, S Griemsmann, R Jabs, G Seifert… - Cell Reports, 2021 - cell.com
Thalamic astrocytes and oligodendrocytes are coupled via gap junctions and form panglial
networks. Here, we show that these networks have a key role in energy supply of neurons …

Adapting brain metabolism to myelination and long‐range signal transduction

J Hirrlinger, KA Nave - Glia, 2014 - Wiley Online Library
In the mammalian brain, the subcortical white matter comprises long‐range axonal
projections and their associated glial cells. Here, astrocytes and oligodendrocytes serve …