Toll-like receptor 4 is expressed on intestinal stem cells and regulates their proliferation and apoptosis via the p53 up-regulated modulator of apoptosis
Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain
incompletely understood. Because ISCs exist among microbial ligands, immune receptors …
incompletely understood. Because ISCs exist among microbial ligands, immune receptors …
Toll-like receptor 4-mediated endoplasmic reticulum stress in intestinal crypts induces necrotizing enterocolitis
The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain
incompletely understood, yet may play a role in diseases characterized by ISC loss …
incompletely understood, yet may play a role in diseases characterized by ISC loss …
Toll-like receptor 2 signaling protects mice from tumor development in a mouse model of colitis-induced cancer
EL Lowe, TR Crother, S Rabizadeh, B Hu, H Wang… - PloS one, 2010 - journals.plos.org
Inflammatory bowel disease (IBD) is a disorder of chronic inflammation with increased
susceptibility to colorectal cancer. The etiology of IBD is unclear but thought to result from a …
susceptibility to colorectal cancer. The etiology of IBD is unclear but thought to result from a …
The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation
SC Gribar, RJ Anand, CP Sodhi… - Journal of Leucocyte …, 2008 - academic.oup.com
Emerging evidence suggests that the innate immune system, comprised of Toll-like
receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of …
receptors (TLRs) and their associated molecules, plays a pivotal role in the regulation of …
Intestinal epithelial Toll-like receptor 4 regulates goblet cell development and is required for necrotizing enterocolitis in mice
BACKGROUND & AIMS: Little is known about factors that regulate intestinal epithelial
differentiation; microbial recognition receptors such as Toll-like receptor (TLR) 4 might be …
differentiation; microbial recognition receptors such as Toll-like receptor (TLR) 4 might be …
Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function
E Cario, G Gerken, DK Podolsky - Gastroenterology, 2007 - Elsevier
Background & Aims: Toll-like receptors (TLRs) represent a class of transmembrane pattern
recognition receptors essential for microbial recognition and control of innate immune …
recognition receptors essential for microbial recognition and control of innate immune …
The role of innate immune-stimulated epithelial apoptosis during gastrointestinal inflammatory diseases
RH Siggers, DJ Hackam - Cellular and Molecular Life Sciences, 2011 - Springer
The maintenance of mucosal barrier equilibrium in the intestine requires a delicate and
dynamic balance between enterocyte loss by apoptosis and the generation of new cells by …
dynamic balance between enterocyte loss by apoptosis and the generation of new cells by …
Innate immune signaling by Toll-like receptor-4 (TLR4) shapes the inflammatory microenvironment in colitis-associated tumors
M Fukata, Y Hernandez, D Conduah… - Inflammatory bowel …, 2009 - academic.oup.com
Background Patients with ulcerative colitis are at increased risk for developing colorectal
cancer. We have shown that Toll-like receptor-4 (TLR4) is overexpressed in human colitis …
cancer. We have shown that Toll-like receptor-4 (TLR4) is overexpressed in human colitis …
Toll-like receptor signaling in small intestinal epithelium promotes B-cell recruitment and IgA production in lamina propria
L Shang, M Fukata, N Thirunarayanan, AP Martin… - Gastroenterology, 2008 - Elsevier
Background & Aims: Several lines of evidence support a role for Toll-like receptor (TLR)
signaling to protect the intestine from pathogenic infection. We hypothesized that TLR …
signaling to protect the intestine from pathogenic infection. We hypothesized that TLR …
Constitutive activation of epithelial TLR4 augments inflammatory responses to mucosal injury and drives colitis-associated tumorigenesis
M Fukata, L Shang, R Santaolalla… - Inflammatory bowel …, 2011 - academic.oup.com
Background Chronic intestinal inflammation culminates in cancer and a link to Toll-like
receptor-4 (TLR4) has been suggested by our observation that TLR4 deficiency prevents …
receptor-4 (TLR4) has been suggested by our observation that TLR4 deficiency prevents …