[HTML][HTML] Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from …

A Gayet-Ageron, D Prieto-Merino, K Ker, H Shakur… - The Lancet, 2018 - thelancet.com
Background Antifibrinolytics reduce death from bleeding in trauma and post-partum
haemorrhage. We examined the effect of treatment delay on the effectiveness of …

Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage

JP Vogel, OT Oladapo, T Dowswell… - The Lancet Global …, 2018 - thelancet.com
Post-partum haemorrhage is the leading cause of maternal mortality globally. 1 The majority
of deaths resulting from post-partum haemorrhage occur during the first 24 h after birth, most …

Anti-fibrinolytic agents in post partum haemorrhage: a systematic review

P Ferrer, I Roberts, E Sydenham, K Blackhall… - BMC pregnancy and …, 2009 - Springer
Background Post partum haemorrhage is a leading cause of maternal death worldwide. It
also contributes to maternal morbidity as women may require a hysterectomy to control …

Antifibrinolytic drugs for treating primary postpartum haemorrhage

H Shakur, D Beaumont, S Pavord… - Cochrane Database …, 1996 - cochranelibrary.com
Background Postpartum haemorrhage (PPH)‐heaving bleeding within the first 24 hours after
giving birth‐is one of the main causes of death of women after childbirth. Antifibrinolytics …

The WOMAN Trial (World Maternal Antifibrinolytic Trial): tranexamic acid for the treatment of postpartum haemorrhage: an international randomised, double blind …

H Shakur, D Elbourne, M Gülmezoglu, Z Alfirevic… - Trials, 2010 - Springer
Background Each year, worldwide about 530,000 women die from causes related to
pregnancy and childbirth. Of the deaths 99% are in low and middle income countries …

Antifibrinolytic drugs for acute traumatic injury

T Coats, IG Roberts, H Shakur - Cochrane Database of …, 2004 - cochranelibrary.com
Background Uncontrolled bleeding is an important cause of death in trauma victims.
Antifibrinolytic treatment has been shown to reduce blood loss following surgery and may …

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international …

H Shakur, I Roberts, B Fawole, R Chaudhri… - The Lancet, 2017 - thelancet.com
Background Post-partum haemorrhage is the leading cause of maternal death worldwide.
Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients …

Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial

N Sprigg, K Flaherty, JP Appleton, RAS Salman… - The Lancet, 2018 - thelancet.com
Background Tranexamic acid can prevent death due to bleeding after trauma and post-
partum haemorrhage. We aimed to assess whether tranexamic acid reduces haematoma …

The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial

Crash-2 Collaborators - The Lancet, 2011 - Elsevier
BACKGROUND: The aim of the CRASH-2 trial was to assess the effects of early
administration of tranexamic acid on death, vascular occlusive events, and blood transfusion …

Antifibrinolytic drugs for acute traumatic injury

K Ker, I Roberts, H Shakur… - Cochrane Database of …, 2015 - cochranelibrary.com
Antifibrinolytic drugs for acute traumatic injury - Ker, K - 2015 | Cochrane Library Skip to
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