Autoantibodies of the cryoprecipitating IgG3 isotype have been shown to play a significant
role in the development of murine lupus–like autoimmune syndrome. At present, the …

Cryoprecipitating IgG3 autoantibodies have been shown to play a significant role in the
development of murine lupus-like autoimmune syndrome. However, the structural basis of …

To analyze the involvement of rheumatoid factors (RF) in the generation of cryoglobulins
and the development of related tissue injuries, we have established a panel of anti-IgG2a …

MRL-lpr/lpr mice spontaneously develop an autoimmune disease resembling systemic
lupus erythematosus and rheumatoid arthritis. One of the unique serological abnormalities …

Abstract A murine IgG3 mAb, 6-19, derived from autoimmune MRL-lpr/lpr mice, is a
rheumatoid factor (RF) specific for IgG2a and is able to generate cryoglobulins via …

Abstract Monoclonal 6-19 IgG3 anti-IgG2a rheumatoid factor derived from lupus-prone MRL-
Fas lpr mice can induce GN and cryoglobulinemia, but the features that confer nephritogenic …

MRL/lpr mice spontaneously develop a lupus‐like autoimmune syndrome characterized by
immunopathologic manifestations such as necrotizing vasculitis of the skin and …

A MRL strain bearing the autosomal recessive mutant gene, lpr (lymphoproliferation),
spontaneously develops, in addition to a lupus-like syndrome, unique serological and …

Cryoglobulin activity associated with murine immunoglobulin G3 (IgG3) has been shown to
play a significant role in the development of murine lupuslike glomerulonephritis. A fraction …

An IgG3 monoclonal antibody, 6-19, derived from unmanipulated MRL/MpJ-lpr/lpr mice,
exhibiting cryoglobulin and anti-IgG2a rheumatoid factor activities, induces skin …