Apoptosis plays a crucial role in maintenance of intestinal epithelial integrity and is highly
regulated by numerous factors, including cellular polyamines. We recently showed that …

It has been documented that polyamines play a critical role in the regulation of apoptosis in
intestinal epithelial cells. We have recently reported that protection from TNF …

The maintenance of intestinal mucosal integrity depends on a balance between cell renewal
and cell death, including apoptosis. The natural polyamines, putrescine, spermidine, and …

Intestinal epithelial (IEC-6) cells are resistant to apoptosis following the inhibition of ODC
(ornithine decarboxylase) and subsequent polyamine depletion. The depletion of …

Apoptosis plays a critical role in the maintenance of gut mucosal homeostasis and is
regulated by numerous factors including polyamines. Although the exact roles of polyamines …

Intracellular polyamine homeostasis is important for the regulation of cell proliferation and
apoptosis and is necessary for the balanced growth of cells and tissues. Polyamines have …

Activation of STAT3 (signal transducer and activator of transcription 3) plays a crucial role in
cell survival and proliferation. The aim of the present study was to clarify the role of STAT3 …

The proliferation of the rat intestinal mucosal IEC-6 cell line requires polyamines, whose
synthesis is catalyzed by the enzyme ornithine decarboxylase (ODC). ODC inhibition leads …

Although p53 is known to play a critical role in the proliferation of gastrointestinal epithelia,
the role of the Mdm2/p53 pathway in response to inducers of apoptosis in intestinal …

Intracellular polyamine synthesis is regulated by the enzyme ornithine decarboxylase
(ODC), and its inhibition by α-difluromethylornithine (DFMO), confers resistance to …