Depression enhanced the production of autoantibodies against 16α‑hydroxyestrone-estrogen receptor adduct in breast cancer

WA Khan, MWA Khan, S Sherwani… - International …, 2019 - Elsevier
Mentally depressed breast cancer (MDBC) patients expressed estrogen receptor (ER) and
16α‑hydroxyestrone (16α‑OHE 1) is directly responsible for causing breast cancer (BC). This …

[HTML][HTML] Depression augments the production of high-affinity antibodies against estrogen metabolite-receptor complex in prostate cancer patients

WA Khan, MWA Khan - 2020 - jomh.org
Background Depression is a common symptom associated with prostate cancer (PC),
elevated levels of 16α-hydroxye-strone (16α-OHE1) have been linked to increased risk of …

16 α-Hydroxyestrone induced adduct generate high affinity autoantibodies in SLE

WA Khan - Advances in medical sciences, 2019 - Elsevier
Abstract Purpose Increased 16 α-hydroxyestrone (16 α-OHE 1) and autoantibodies against
histone H1 (H 1) have been well described in systemic lupus erythematosus (SLE), but the …

Endometrial cancer patients have high affinity antibodies for estrogen metabolite–receptor aggregate: a potential biomarker for EC

WA Khan, AS Alsamghan… - Journal of Obstetrics and …, 2020 - Wiley Online Library
Aim Elevated levels of 16α‐hydroxyestrone (16α‐OHE1) have been described in
endometrial cancer (EC) and estrogen receptors (ER) expressed in endometrial tissue, but …

Detection of 16α-hydroxyestrone-histone 1 adduct as high-affinity antigen for rheumatoid arthritis autoantibodies

WA Khan, GS Zaman - Archivum Immunologiae et Therapiae …, 2018 - Springer
Increased concentrations of 16α-hydroxyestrone (16α-OHE 1) have been observed in
rheumatoid arthritis (RA), but the underlying mechanism of this remains elusive. Here we …

Evaluation of an EIA method for measuring serum levels of the estrogen metabolite 2-hydroxyestrone in adults

FW Spierto, F Gardner, SJ Smith - Steroids, 2001 - Elsevier
Two-hydroxyestrone (2OHE-1) and 16α-hydroxyestrone (16OHE-1) are two estrogen
metabolites that may play important roles in the development or promotion of breast cancer …

New insights into the protective effects of DHEA1)

S Niro, O Hennebert, R Morfin - Hormone Molecular Biology and …, 2010 - degruyter.com
Numerous studies investigated the effects of pharmacological doses of DHEA in animals.
Among protective effects, antiglucocorticoid potencies, triggering and modulation of …

Autoantibodies specific to estrogen receptor alpha act as estrogen agonists and their levels correlate with breast cancer cell proliferation

A Maselli, S Capoccia, P Pugliese, C Raggi… - …, 2016 - Taylor & Francis
Estrogen receptors have recently been demonstrated at the cell surface. Unlike nuclear
receptors, they are able to trigger rapid responses inside the cells. In this study, we …

The DHEA metabolite 7β-hydroxy-epiandrosterone exerts anti-estrogenic effects on breast cancer cell lines

S Niro, E Pereira, MA Pélissier, R Morfin, O Hennebert - Steroids, 2012 - Elsevier
7β-Hydroxy-epiandrosterone (7β-OH-EpiA), an endogenous androgenic derivative of
dehydroepiandrosterone, has previously been shown to exert anti-inflammatory action in …

[PDF][PDF] Production and characterization of anti-estrone monoclonal antibody

W YONG-CHENG, GUO ZHEN-QUAN… - Biomedical and …, 2002 - besjournal.com
Objective Determination of estrone (E1) levels has a significant meaning in evaluating
physiological effect and diagnosing some diseases. In order to detect free E1 in biological …