Differentiating neurons derived from human umbilical cord blood stem cells work as a test system for developmental neurotoxicity

MP Kashyap, V Kumar, AK Singh, VK Tripathi… - Molecular …, 2015 - Springer
Differentiating neuronal cells derived from human umbilical cord blood stem cells have been
used as an in vitro tool for the assessment of developmental neurotoxicity of monocrotophos …

Progress toward the development of in vitro model system for chemical-induced developmental neurotoxicity: potential applicability of stem cells

V Kumar, S Jahan, S Singh, VK Khanna, AB Pant - Archives of toxicology, 2015 - Springer
In our so far published papers, we have successfully attempted to establish stem cell-based
in vitro model systems for the study of the various aspects of DNT and have proven that …

Human cord blood-derived neural stem cell line—possible implementation in studying neurotoxicity

L Bużańska, A Habich, M Jurga, J Sypecka… - Toxicology in Vitro, 2005 - Elsevier
Neural stem cell line developed from human umbilical cord blood (HUCB-NSC)[Bużańska et
al., 2003. Journal of Neurochemistry 85, 33] is an ethically uncontroversial source of stem …

Effects of chlorpyrifos on cell death and cellular phenotypic specification of human neural stem cells

L Sandoval, A Rosca, A Oniga, A Zambrano… - Science of The Total …, 2019 - Elsevier
Chlorpyrifos (CPF) is an organophosphate pesticide widely used in agriculture, whose
traditional and well-known mechanism of action is the inhibition of the enzyme …

Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus …

D Pamies, MA Sogorb, M Fabbri, L Gribaldo… - International journal of …, 2014 - mdpi.com
Historically, only few chemicals have been identified as neurodevelopmental toxicants,
however, concern remains, and has recently increased, based upon the association …

An Overview on Human Umbilical Cord Blood Stem Cell-Based Alternative In Vitro Models for Developmental Neurotoxicity Assessment

AK Singh, MP Kashyap - Molecular neurobiology, 2016 - Springer
The developing brain is found highly vulnerable towards the exposure of different
environmental chemicals/drugs, even at concentrations, those are generally considered safe …

Human Umbilical Cord Mesenchymal Stem Cell–Based in vitro Model for Neurotoxicity Testing

T Coccini, A Spinillo, M Roccio, E Lenta… - Current …, 2022 - Wiley Online Library
Neurotoxicity (NT) testing for regulatory purposes is based on in vivo animal testing. There is
general consensus, however, about the need for the development of alternative …

Human umbilical cord blood-derived neural stem cell line as a screening model for toxicity

R Patnaik, RN Padhy - Neurotoxicity research, 2017 - Springer
The aim was to investigate whether a human neural stem cell (NSC) line derived from
human umbilical cord blood (hUCB) can be used for toxicity study. Toxicity of both …

Study of the chlorpyrifos neurotoxicity using neural differentiation of adipose tissue‐derived stem cells

MH Zarei, M Soodi… - Environmental …, 2016 - Wiley Online Library
Chlorpyrifos (CPF) is the most commonly used organophosphorus insecticide which causes
neurodevelopmental toxicity. So far, animals have been used as ideal models for …

Umbilical cord blood stem cells–potential therapeutic tool for neural injuries and disorders

H Ali, H Bahbahani - Acta Neurobiologiae Experimentalis, 2010 - ane.pl
Brain limited self-renewal capability is the main element behind the seriousness of
neurodegenerative diseases and neural injuries. Any possible attempts to use cell …