Both peripheral nerve injury and chronic opioid treatment can result in hyperalgesia
associated with enhanced excitatory neurotransmission at the level of the spinal cord …

Studies in experimental models and controlled patient trials indicate that opioids are
effective in managing neuropathic pain. However, side effects secondary to their central …

Besides generally accepted lower analgesic potencies of opioids in neuropathic pain, our
recent pharmacological reports have demonstrated that the effectiveness of the μ-opioid …

Previously, we reported that oxycodone is a putative κ-opioid agonist based on studies
where intracerebroventricular (icv) pre-treatment of rats with the κ-selective opioid …

Potent opioid-based therapies are often unsuccessful in promoting satisfactory analgesia in
neuropathic pain. Moreover, the side effects associated with opioid therapy are still …

In both the spared nerve injury (SNI) and spinal nerve ligation (SNL) rat peripheral
neuropathic pain models the presynaptic inhibitory effect of the μ opioid receptor (MOR) …

Despite using prescribed pain medications, patients with neuropathic pain continue to
experience moderate to severe pain. There is a growing recognition of a potent peripheral …

Opioids are widely prescribed for chronic pain, including neuropathic pain, despite growing
evidence of long-term harm. Previous preclinical studies have documented exacerbation of …

Preclinical studies have suggested that opioid exposure may induce a paradoxical decrease
in the nociceptive threshold, commonly referred as opioid-induced hyperalgesia (OIH) …

A sound strategy for improving the clinical efficacy of opioids involves exploiting positive
interactions with drugs directed at other targets in pain pathways. The current study …