Scanning fluorescence correlation spectroscopy is a new approach to measuring changes
in the state of aggregation of cell membrane proteins. Measurements of the mean number of …

Scanning Fluorescence Correlation Spectroscopy (S-FCS) is introduced as an adaptation of
Fluorescence Correlation Spectroscopy (FCS) to measure aggregation in systems, such as …

It is demonstrated that fluorescence resonance energy transfer may be used to determine
the fractal dimension of aggregates of membrane-bound proteins. Theoretical and …

A method for simultaneous determination of molar weights (M) and lateral diffusion
constants (D) of particles in three-and two-dimensional systems is described. Spontaneous …

Communication between cells invariably involves interactions of a signalling molecule with
a receptor at the surface of the cell. Typically, the receptor is imbedded in the membrane and …

The technique of high-order fluorescence fluctuation autocorrelation for detecting and
characterizing protein oligomers was applied to solutions containing two fluorescent …

The preceding paper by Douglas Magde has recounted the basic principles of Fluorescence
Correlation Spectroscopy (FCS) as originally described (see Magde, Elson & Webb, 1972; …

The formation of cell surface receptor clusters has been implicated of confirmed in the
mechanism of signal transduction across biological membranes for a variety of processes …

Phage display is widely used for expression of combinatorial libraries, not least for protein
engineering purposes. Precise selection at the single molecule level will provide an …

A simple, straightforward analysis to characterize the distribution of aggregate sizes in a
reversible aggregation system at equilibrium is presented. The method, an extension of …