Background. We developed a 2-step approach to screen molecules that prevent and/or
reverse Plasmodium falciparum–infected erythrocyte (IE) binding to host receptors. IE …

Cytoadhesion of Plasmodium falciparum-infected erythrocytes (IEs) to the endothelial lining
of blood vessels protects parasites from splenic destruction, but also leads to detrimental …

A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the
adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected …

Rosetting, the adhesion of Plasmodium falciparum-infected erythrocytes to uninfected
erythrocytes, involves clonal variants of the parasite protein P. falciparum erythrocyte …

The virulence of Plasmodium falciparum is linked to the ability of infected erythrocytes (IE) to
adhere to the vascular endothelium, mediated by P. falciparum erythrocyte membrane …

Attachment of erythrocytes infected by Plasmodium falciparum to receptors of the
microvasculature is a major contributor to the pathology and morbidity associated with …

The parasite ligand Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) and
host endothelial receptors represent potential targets for antiadhesive therapy for …

PfEMP1 is a family of adhesive proteins expressed on the surface of Plasmodium falciparum-
infected erythrocytes (IEs), where they mediate adhesion of IEs to a range of host receptors …

Background Sequestration of parasitized red blood cells from the peripheral circulation
during an infection with Plasmodium falciparum is caused by an interaction between the …

Plasmodium falciparum-infected red blood cells adhere to endothelial cells, thereby
obstructing the microvasculature. Erythrocyte adherence is directly associated with severe …