Toll-like receptors

K Takeda, T Kaisho, S Akira - Annual review of immunology, 2003 - annualreviews.org
The innate immune system in drosophila and mammals senses the invasion of
microorganisms using the family of Toll receptors, stimulation of which initiates a range of …

The role of Toll-like receptors in host defense against microbial infection

SR Krutzik, PA Sieling, RL Modlin - Current opinion in immunology, 2001 - Elsevier
The Toll family of proteins is central to Drosophila host defense against microbial infection.
Maintained throughout evolution, mammalian Toll-like receptors (TLRs) are proteins that …

Toll signaling pathways in the innate immune response

KV Anderson - Current opinion in immunology, 2000 - Elsevier
The Toll signaling pathway, which is required for the establishment of the dorsal–ventral axis
in Drosophila embryos, plays an important role in the response of larval and adult …

[HTML][HTML] The biology of Toll-like receptors

TK Means, DT Golenbock, MJ Fenton - Cytokine & growth factor reviews, 2000 - Elsevier
In 1997, a human homologue of the Drosophila Toll protein was described, a protein later to
be designated Toll-like receptor 4 (TLR4). Since that time, additional human and murine …

Toll‐like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes

M Muzio, N Polentarutti, D Bosisio… - Journal of leukocyte …, 2000 - Wiley Online Library
Toll is a Drosophila gene essential for ontogenesis and antimicrobial resistance. Several
hortologues of Toll have been identified and cloned in vertebrates, namely Toll‐like …

Critical roles of Toll-like receptors in host defense

T Kaisho, S Akira - Critical Reviews™ in Immunology, 2000 - dl.begellhouse.com
Drosophila Toll is involved not only in dorsoventral patterning of embryos but also in
immune responses to microbial infection. Several Toll-like receptors (TLRs) have also been …

Toll-like receptor family and signalling pathway

M Muzio, N Polentarutti, D Bosisio… - Biochemical society …, 2000 - portlandpress.com
Toll is a Drosophila gene essential for ontogenesis and anti-microbial resistance. Several
orthologues of Toll have been identified and cloned in vertebrates, namely Toll-like …

Toll-like receptors: lessons from knockout mice

S Akira - Biochemical Society Transactions, 2000 - portlandpress.com
The Toll signalling pathway, which is required for establishment of dorsoventral polarity in
Drosophila embryos, plays an important role in the response to microbial infections …

Toll-like receptors: mammalian 'taste receptors' for a smorgasbord of microbial invaders

PA Sieling, RL Modlin - Current opinion in microbiology, 2002 - Elsevier
In Drosophila, the Toll family of proteins is responsible for the recognition of bacteria and
fungi. In mammals, Toll-like receptors (TLRs) are able to recognize and respond to microbial …

Structure and function of Toll-like receptor proteins

TK Means, DT Golenbock, MJ Fenton - Life sciences, 2000 - Elsevier
Beginning in 1997 with the identification of the first human homologue of the Drosophila
protein Toll, a family of related molecules have been identified in both humans and other …