Mammalian Cdh1/Fzr mediates its own degradation
T Listovsky, YS Oren, Y Yudkovsky… - The EMBO …, 2004 - embopress.org
The A naphase‐P romoting C omplex/C yclosome (APC/C) ubiquitin ligase mediates
degradation of cell cycle proteins during mitosis and G1. Cdc20/Fzy and Cdh1/Fzr are …
degradation of cell cycle proteins during mitosis and G1. Cdc20/Fzy and Cdh1/Fzr are …
Involvement of the SCF complex in the control of Cdh1 degradation in S-phase
R Benmaamar, M Pagano - Cell Cycle, 2005 - Taylor & Francis
The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that
acts as a key regulator in the progression through mitosis (when mostly in complex with …
acts as a key regulator in the progression through mitosis (when mostly in complex with …
The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1
CM Pfleger, MW Kirschner - Genes & development, 2000 - genesdev.cshlp.org
The ordered progression through the cell cycle depends on regulating the abundance of
several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and …
several proteins through ubiquitin-mediated proteolysis. Degradation is precisely timed and …
Mitotic regulation of the APC activator proteins CDC20 and CDH1
ER Kramer, N Scheuringer… - Molecular biology of …, 2000 - Am Soc Cell Biol
The ordered activation of the ubiquitin protein ligase anaphase-promoting complex (APC) or
cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase …
cyclosome by CDC20 in metaphase and by CDH1 in telophase is essential for anaphase …
Interplay between Cdh1 and JNK activity during the cell cycle
GJ Gutierrez, T Tsuji, M Chen, W Jiang, ZA Ronai - Nature cell biology, 2010 - nature.com
The ubiquitin ligase APC/CCdh1 coordinates degradation of key cell cycle regulators. We
report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded …
report here that a nuclear-localized portion of the stress-activated kinase JNK is degraded …
Multi-kinase phosphorylation of the APC/C activator Cdh1 revealed by mass spectrometry
MC Hall, EN Warren, CH Borchers - Cell Cycle, 2004 - Taylor & Francis
by activating a large ubiquitin ligase called the anaphase-promoting complex, or cyclosome
(APC/C). At the end of G1, APC/CCdh1 is inhibited by cyclin-dependent kinase (CDK) …
(APC/C). At the end of G1, APC/CCdh1 is inhibited by cyclin-dependent kinase (CDK) …
[HTML][HTML] Assembly of an APC-Cdh1-substrate complex is stimulated by engagement of a destruction box
JL Burton, V Tsakraklides, MJ Solomon - Molecular cell, 2005 - cell.com
The anaphase-promoting complex (APC) is a ubiquitin ligase that promotes the degradation
of cell-cycle regulators. Cdh1p is an APC coactivator that directly binds APC substrates. A …
of cell-cycle regulators. Cdh1p is an APC coactivator that directly binds APC substrates. A …
[HTML][HTML] Inhibition of APCCdh1 activity by Cdh1/Acm1/Bmh1 ternary complex formation
JM Dial, EV Petrotchenko, CH Borchers - Journal of Biological Chemistry, 2007 - ASBMB
The anaphase-promoting complex (APC) is an essential E3 ubiquitin ligase responsible for
catalyzing proteolysis of key regulatory proteins in the cell cycle. Cdh1 is a co-activator of the …
catalyzing proteolysis of key regulatory proteins in the cell cycle. Cdh1 is a co-activator of the …
[HTML][HTML] Nuclear localization of the cell cycle regulator CDH1 and its regulation by phosphorylation
Y Zhou, YP Ching, ACS Chun, DY Jin - Journal of Biological Chemistry, 2003 - ASBMB
The anaphase-promoting complex activated by CDC20 and CDH1 is a major ubiquitination
system that controls the destruction of cell cycle regulators. Exactly how ubiquitination is …
system that controls the destruction of cell cycle regulators. Exactly how ubiquitination is …
[HTML][HTML] Yeast Hct1 recognizes the mitotic cyclin Clb2 and other substrates of the ubiquitin ligase APC
M Schwab, M Neutzner, D Möcker, W Seufert - The EMBO journal, 2001 - embopress.org
Ubiquitin‐mediated proteolysis has emerged as a key mechanism of regulation in eukaryotic
cells. During cell division, a multi‐subunit ubiquitin ligase termed the anaphase promoting …
cells. During cell division, a multi‐subunit ubiquitin ligase termed the anaphase promoting …