Therapeutic applications and mechanisms underlying the activity of immunosuppressive oligonucleotides
DM Klinman, D Tross, S Klaschik… - Annals of the New …, 2009 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODN) capable of “neutralizing” or “inhibiting” immune
responses have been described. This review will focus on the properties of …
responses have been described. This review will focus on the properties of …
Therapeutic potential of oligonucleotides expressing immunosuppressive TTAGGG motifs
DM Klinman, I Gursel, S Klaschik… - Annals of the New …, 2005 - Wiley Online Library
Synthetic oligodeoxynucleotides (ODNs) expressing immunosuppressive TTAGGG motifs
downregulate the production of proinflammatory and Th1 cytokines. The ability of these …
downregulate the production of proinflammatory and Th1 cytokines. The ability of these …
Suppressive oligodeoxynucleotides delay the onset of glomerulonephritis and prolong survival in lupus‐prone NZB× NZW mice
Objective Synthetic oligodeoxynucleotides (ODN) expressing TTAGGG motifs suppress the
production of proinflammatory cytokines and have been proven effective at blocking the …
production of proinflammatory cytokines and have been proven effective at blocking the …
Suppressive oligodeoxynucleotides inhibit Th1 differentiation by blocking IFN-γ-and IL-12-mediated signaling
H Shirota, M Gursel, DM Klinman - The Journal of Immunology, 2004 - journals.aai.org
Repetitive TTAGGG motifs present at high frequency in mammalian telomeres can suppress
Th1-mediated immune responses. Synthetic oligonucleotides (ODN) containing TTAGGG …
Th1-mediated immune responses. Synthetic oligonucleotides (ODN) containing TTAGGG …
Suppressive oligodeoxynucleotides promote the development of Th17 cells
C Bode, XP Yang, H Kiu, DM Klinman - PloS one, 2013 - journals.plos.org
Synthetic oligonucleotides containing repetitive TTAGGG motifs mimic the
immunosuppressive activity of telomeric DNA. These suppressive oligonucleotides (Sup …
immunosuppressive activity of telomeric DNA. These suppressive oligonucleotides (Sup …
Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation
C Bode, J Wang, DM Klinman - International immunopharmacology, 2014 - Elsevier
Suppressive oligodeoxynucleotides (Sup ODN) express repetitive TTAGGG motifs that have
proven useful in the treatment/prevention of numerous inflammatory and autoimmune …
proven useful in the treatment/prevention of numerous inflammatory and autoimmune …
Synthetic oligonucleotides as modulators of inflammation
D Klinman, H Shirota, D Tross, T Sato… - Journal of Leucocyte …, 2008 - academic.oup.com
Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and …
immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate human B cells and …
Inhibition of a C‐rich oligodeoxynucleotide on activation of immune cells in vitro and enhancement of antibody response in mice
G Yang, M Wan, Y Zhang, L Sun, R Sun, D Hu… - …, 2010 - Wiley Online Library
To explore the possibility that human mitochondrial genomic DNA‐mimicking
oligodeoxynucleotides could regulate the immune response, a series of mitochondrial DNA …
oligodeoxynucleotides could regulate the immune response, a series of mitochondrial DNA …
Synthetic oligodeoxynucleotides containing suppressive TTAGGG motifs inhibit AIM2 inflammasome activation
JJ Kaminski, SA Schattgen, TC Tzeng… - The Journal of …, 2013 - journals.aai.org
Synthetic oligodeoxynucleotides (ODNs) comprised of the immunosuppressive motif
TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a …
TTAGGG block TLR9 signaling, prevent STAT1 and STAT4 phosphorylation and attenuate a …
Modulation of endosomal Toll-like receptor-mediated immune responses by synthetic oligonucleotides
ER Kandimalla, S Agrawal - Nucleic Acid Drugs, 2012 - Springer
Abstract Toll-like receptors (TLRs) 7, 8, and 9 belong to a family of endosomal receptors that
are known to detect pathogen-associated nucleic acid molecular patterns and induce …
are known to detect pathogen-associated nucleic acid molecular patterns and induce …