Self-assembled pH-responsive DNA nanosponges for targeted co-delivery of doxorubicin and capsaicin for colorectal cancer therapy
DNA nanostructures have been engineered into various delivery systems for anti-cancer
chemotherapy. However, these nanostructures are hindered in their therapeutic applications …
chemotherapy. However, these nanostructures are hindered in their therapeutic applications …
Cocoon-like self-degradable DNA nanoclew for anticancer drug delivery
A bioinspired cocoon-like anticancer drug delivery system consisting of a
deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid …
deoxyribonuclease (DNase)-degradable DNA nanoclew (NCl) embedded with an acid …
A self-assembled DNA nanostructure for targeted and pH-triggered drug delivery to combat doxorubicin resistance
We developed a novel self-assembled DNA nanostructure for anticancer drug delivery. The
resulting nanostructure was able to specifically target cancer cells and release the loaded …
resulting nanostructure was able to specifically target cancer cells and release the loaded …
Nanosponge-mediated oligonucleotide delivery: A cutting-edge technology towards cancer management
Recently, oligonucleotides have attracted substantial attention in the field of cancer therapy
due to their target specificity and ability to modulate various molecular pathways. However …
due to their target specificity and ability to modulate various molecular pathways. However …
pH-responsive and gemcitabine-containing DNA nanogel to facilitate the chemodrug delivery
Herein, we construct a structure-switchable gemcitabine (Ge)-containing DNA nanogel that
can respond to the intracellular acidic environment, subsequently facilitating the chemodrug …
can respond to the intracellular acidic environment, subsequently facilitating the chemodrug …
Size controllable DNA nanogels from the self-assembly of DNA nanostructures through multivalent host–guest interactions
Nanogels made of biomolecules are one of the potential candidates as a nanocarrier for
drug delivery applications. The unique structural characteristics and excellent …
drug delivery applications. The unique structural characteristics and excellent …
Layer-by-layer assembled antisense DNA microsponge particles for efficient delivery of cancer therapeutics
Antisense oligonucleotides can be employed as a potential approach to effectively treat
cancer. However, the inherent instability and inefficient systemic delivery methods for …
cancer. However, the inherent instability and inefficient systemic delivery methods for …
Dual-functional DNA nanogels for anticancer drug delivery
H Zhu, J Wu, J Zhao, L Yu, BR Liyarita, X Xu, Y Xiao… - Acta Biomaterialia, 2024 - Elsevier
DNA hydrogels with unique sequence programmability on nucleic acid framework manifest
remarkable attributes, such as high payload capacities, biocompatibility and biosafety. The …
remarkable attributes, such as high payload capacities, biocompatibility and biosafety. The …
Naturally derived DNA nanogels as pH-and glutathione-triggered anticancer drug carriers
YF Chen, MW Hsu, YC Su, HM Chang… - Materials Science and …, 2020 - Elsevier
Conventional chemotherapeutic drugs are nonselective and harmful toward normal tissues,
causing severe side effects. Therefore, the development of chemotherapeutics that can …
causing severe side effects. Therefore, the development of chemotherapeutics that can …
Sequence‐Independent DNA Nanogel as a Potential Drug Carrier
DNA nanostructures largely rely on pairing DNA bases; thus, sequence designing is
required. Here, this study demonstrates a sequence‐independent strategy to fabricate DNA …
required. Here, this study demonstrates a sequence‐independent strategy to fabricate DNA …
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