Warm and cold hepatic ischemia followed by reperfusion leads to necrotic cell death
(oncosis), which often occurs within minutes of reperfusion. Recent studies also suggest a …

Reperfusion of ATP-depleted tissues after warm or cold ischemia causes pH-dependent
necrotic and apoptotic cell death. In hepatocytes and other cell types as well, the mechanism …

Background & Aims: Ischemia/reperfusion can initiate both necrotic and apoptotic death of
hepatocytes. Previous work showed that onset of the mitochondrial permeability transition …

Death of hepatocytes and other hepatic cell types is a characteristic feature of liver diseases
as diverse as cholestasis, viral hepatitis, ischemia/reperfusion, liver preservation for …

Liver cell death is triggered by a number of insults arising from the external environment or
from within the cell. These insults may engage cell surface receptors with death domaines …

In addition to playing a pivotal role in cellular energetics and biosynthesis, mitochondrial
components are key operators in the regulation of cell death. In addition to apoptosis …

Hepatic ischemia-reperfusion injury is a major cause of post-operative hepatic dysfunction
and liver failure after transplantation. Mitochondrial pathways can be either beneficial or …

Acute liver failure (ALF) occurs when the rate and extent of liver cell death are not
adequately balanced by regenerative activity. Two forms of liver cell death are recognized …

Derangements in apoptosis of liver cells are mechanistically important in the pathogenesis
of end-stage liver disease. Vulnerable hepatocytes can undergo apoptosis via an extrinsic …

Apoptosis is a prominent feature of liver diseases. Causative factors such as alcohol,
viruses, toxic bile acids, fatty acids, drugs, and immune response, can induce apoptotic cell …