Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated
by processes of fission and fusion. We hypothesized that the mitochondria fusion protein …

Mitochondrial fission, regulated by dynamin-related protein-1 (Drp1), is a newly recognized
determinant of mitochondrial function, but its contribution to left ventricular (LV) impairment …

Rationale: Both fusion and fission contribute to mitochondrial quality control. How
unopposed fusion affects survival of cardiomyocytes and left ventricular function in the heart …

Background—Whether alterations in mitochondrial morphology affect the susceptibility of the
heart to ischemia/reperfusion injury is unknown. We hypothesized that modulating …

Myocardial ischemia–reperfusion (I/R) injury is one of the leading causes of death and
disability worldwide. Mitochondrial fission has been shown to be involved in cardiomyocyte …

804 DHINGRA R et al. inactivate its GTPases activity and fission. 22, 23 In the context of the
heart, myocardial ischemia-reperfusion (IR) injury remains a major cause of morbidity and …

Recent attention has focused on the concept that mitochondrial dynamics—that is, the
balance between mitochondrial fusion and fission (fragmentation)—may play a pivotal role …

Background Mitochondria constitute 30% of cell volume and are engaged in two dynamic
processes called fission and fusion, regulated by Drp-1 (dynamin related protein) and …

Mitochondria are extraordinarily dynamic organelles that have a variety of morphologies, the
status of which are controlled by the opposing processes of fission and fusion. Our recent …

Mitochondria are highly dynamic organelles undergoing cycles of fusion and fission to
modulate their morphology, distribution, and function, which are referred as 'mitochondrial …