Kinases play a prominent role in tumor development, pointing to the presence of specific
phosphorylation patterns in tumor tissues. Here, we investigate whether recently developed …

Proteomics is optimally suited to bridge the gap between genomic information on the one
hand and biologic functions and disease phenotypes at the other, since it studies the …

Despite impressive scientific achievements over the past few decades, cancer is still a
leading cause of death. One of the major reasons is that most cancer patients are diagnosed …

Phosphorylation of proteins is a key way cells regulate function, both at the individual protein
level and at the level of signaling pathways. Kinases are responsible for phosphorylation of …

Numerous omics studies, primarily genomics analyses, have been conducted to fully
understand the molecular biological characteristics of cancer. In recent years, the depth of …

Proteomics analysis has been heralded as a novel tool for identifying new and specific
biomarkers that may improve diagnosis and monitoring of various disease states. Recent …

Systematic studies of the cancer genome have generated a wealth of knowledge in recent
years. These studies have uncovered a number of new cancer genes not previously known …

Tumor tissue processing methodologies in combination with data‐independent acquisition
mass spectrometry (DIA‐MS) have emerged that can comprehensively analyze the …

Early diagnosis and prevention is crucial for reducing the mortality and morbidity of cancer.
Current clinical examination, such as mammography and invasive needle or surgical …

The revolution in genomics and proteomics has produced complex technologies enabling
an insight into the functional effectors of cellular processes. In oncology these technologies …