Multi-drug resistance (MDR) is a curious bottleneck in cancer research and chemotherapy,
whereby some cells rapidly adapt to the tumor microenvironment via a myriad of …

Mulitdrug resistance (MDR) is one of critical factorslimiting the efficacy of cancer chemoor
radiotherapy. Emerging evidence has indicated that MDR is a complex process regulated by …

Background The AMP-activated protein kinase (AMPK) is an evolutionarily conserved
regulator of cellular energy homeostasis. As a nexus for transducing metabolic signals …

The AMP-activated protein kinase (AMPK) is a sensor of cellular energy status expressed in
essentially all eukaryotic cells. Once activated by energetic stress via a mechanism that …

AMP-activated protein kinase (AMPK) plays a pivotal role in maintaining energy and redox
homeostasis under various metabolic stress conditions. Metabolic adaptation, which can be …

The mitogen-activated protein kinase (MAPK) pathways are crucial regulators of the cellular
processes that fuel the malignant transformation of normal cells. The molecular aberrations …

AMP‐activated kinase (AMPK) is a central cellular energetic biosensor and regulator of a
broad array of cellular metabolic routes activated by nutrient deprivation, mitochondrial …

Background and purpose Multidrug resistance (MDR) is a major obstacle to the successful
treatment of cancer. Ample evidence shows that ATP‐binding cassette (ABC) transporters …

Background Nutrient acquisition and metabolism pathways are altered in cancer cells to
meet bioenergetic and biosynthetic demands. A major regulator of cellular metabolism and …

This chapter focuses on the role of AMPK as a stress-response molecule with an emphasis
on its duplex implication in carcinogenesis and cancer drug resistance. AMPK is closely …