The development of diet-induced obesity (DIO) can potently alter multiple aspects of
dopamine signaling, including dopamine transporter (DAT) expression and dopamine …

Objective To test whether high‐fat diet (HFD) decreases dopaminergic tone in reward
regions of the brain and evaluate whether these changes reverse after removal of the HFD …

Objective: A rat model of diet-induced obesity (DIO) was used to determine dopamine
transporter (DAT) function, impulsivity and motivation as neurobehavioral outcomes and …

Objective We have previously demonstrated that insulin signaling, through the downstream
signaling kinase Akt, is a potent modulator of dopamine transporter (DAT) activity, which fine …

Different types of high‐fat (HF) diets are used to study diet‐induced obesity (DIO) in rodents
and this has led to different phenotypes. This study assesses whether different HF diets …

Dopaminergic signaling in the striatum, particularly at dopamine 2 receptors (D2R), has
been a topic of active investigation in obesity research in the past decades. However, it still …

Highlights•Chronic high-fat feeding modulates dopamine tone and function.•The impact of
high-fat diet on dopamine-related endpoints is inconsistent.•Classification of results …

In 2010, Johnson and Kenny provided conclusive evidence that extended access to a
Western-style diet promotes addictive-like behavior in rats by downregulating D2 receptors …

J. Neurochem.(2012) 120, 891–898. Abstract Chronic intake of high‐fat (HF) diet is known to
alter brain neurotransmitter systems that participate in the central regulation of food intake …

Mesolimbic dopamine (DA) signaling has been implicated in the incentive, reinforcing and
motivational aspects of food intake. Insulin receptors are expressed on dopaminergic …