Maternal Genistein Alters Coat Color and Protects Avy Mouse Offspring from Obesity by Modifying the Fetal Epigenome
DC Dolinoy, JR Weidman… - Environmental health …, 2006 - ehp.niehs.nih.gov
Genistein, the major phytoestrogen in soy, is linked to diminished female reproductive
performance and to cancer chemoprevention and decreased adipose deposition. Dietary …
performance and to cancer chemoprevention and decreased adipose deposition. Dietary …
Epigenetics: prenatal exposure to genistein leaves a permanent signature on the hematopoietic lineage
K Vanhees, S Coort, EJB Ruijters… - The FASEB …, 2011 - Wiley Online Library
Recent studies demonstrate that maternal diet during pregnancy results in long‐lasting
effects on the progeny. Supplementation of maternal diet with genistein, a phytoestrogen …
effects on the progeny. Supplementation of maternal diet with genistein, a phytoestrogen …
[HTML][HTML] Improved glucose and lipid metabolism in the early life of female offspring by maternal dietary genistein is associated with alterations in the gut microbiota
L Zhou, X Xiao, Q Zhang, J Zheng, M Li, M Yu… - Frontiers in …, 2018 - frontiersin.org
Maternal over-nutrition can lead to metabolic disorders in offspring, whereas maternal
dietary genistein may have beneficial effects on the metabolic health of offspring. Our …
dietary genistein may have beneficial effects on the metabolic health of offspring. Our …
[HTML][HTML] Genistein chemoprevention: timing and mechanisms of action in murine mammary and prostate
CA Lamartiniere, MS Cotroneo, WA Fritz, J Wang… - The Journal of …, 2002 - Elsevier
We investigated the potential of genistein, the primary isoflavone of soy, to protect against
breast and prostate cancers in animal models. For mammary cancer studies, Sprague …
breast and prostate cancers in animal models. For mammary cancer studies, Sprague …
Genistein, an epigenome modifier during cancer prevention
Y Zhang, H Chen - Epigenetics, 2011 - Taylor & Francis
Dietary compounds have been observed to have a great potential to regulate the
epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their …
epigenome, which is disrupted and reprogrammed during carcinogenesis. Because of their …
Circulating levels of genistein in the neonate, apart from dose and route, predict future adverse female reproductive outcomes
WN Jefferson, CJ Williams - Reproductive toxicology, 2011 - Elsevier
Developmental exposure to estrogenic compounds can disrupt sexual differentiation and
adult reproductive function in many animals including humans. Phytoestrogens (plant …
adult reproductive function in many animals including humans. Phytoestrogens (plant …
Prepubertal estradiol and genistein exposures up-regulate BRCA1 mRNA and reduce mammary tumorigenesis
A Cabanes, M Wang, S Olivo, S DeAssis… - …, 2004 - academic.oup.com
Prepubertal exposure to soy or its biologically active component genistein reduces later
breast cancer risk in both animal models and human populations. We investigated whether …
breast cancer risk in both animal models and human populations. We investigated whether …
[HTML][HTML] Impact of soy isoflavones on the epigenome in cancer prevention
M Pudenz, K Roth, C Gerhauser - Nutrients, 2014 - mdpi.com
Isoflavones (IF) such as genistein are cancer preventive phytochemicals found in soy and
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …
other legumes. Epidemiological studies point to a reduced risk for hormone‑dependent …
Prenatal nutrition and the risk of adult obesity: long-term effects of nutrition on epigenetic mechanisms regulating gene expression
E Navarro, AN Funtikova, M Fíto, H Schröder - The Journal of nutritional …, 2017 - Elsevier
Solid epidemiological evidence indicates that part of the risk of obesity in adulthood could
be programmed during prenatal development by the quality of maternal nutrition …
be programmed during prenatal development by the quality of maternal nutrition …
Genistein studies in rats: potential for breast cancer prevention and reproductive and developmental toxicity
CA Lamartiniere, JX Zhang, MS Cotroneo - The American journal of clinical …, 1998 - Elsevier
Asian women and men who consume a traditional diet high in soy products have low
incidences of breast and prostate cancers, respectively. Yet Asians who immigrate to the …
incidences of breast and prostate cancers, respectively. Yet Asians who immigrate to the …