Autoantibodies to lipoprotein-related protein 4 in patients with double-seronegative myasthenia gravis

B Zhang, JS Tzartos, M Belimezi, S Ragheb… - Archives of …, 2012 - jamanetwork.com
Objectives To determine whether patients with myasthenia gravis (MG) have serum
antibodies to lipoprotein-related protein 4 (LRP4), a newly identified receptor for agrin that is …

Anti-LRP4 autoantibodies in AChR-and MuSK-antibody-negative myasthenia gravis

A Pevzner, B Schoser, K Peters, NC Cosma… - Journal of …, 2012 - Springer
Myasthenia gravis (MG) is an autoimmune disorder characterized by a defect in synaptic
transmission at the neuromuscular junction causing fluctuating muscle weakness with a …

Antibodies against low-density lipoprotein receptor–related protein 4 induce myasthenia gravis

C Shen, Y Lu, B Zhang, D Figueiredo… - The Journal of …, 2013 - Am Soc Clin Investig
Myasthenia gravis (MG) is the most common disorder affecting the neuromuscular junction
(NMJ). MG is frequently caused by autoantibodies against acetylcholine receptor (AChR) …

Autoantibodies to agrin in myasthenia gravis patients

B Zhang, C Shen, B Bealmear, S Ragheb, WC Xiong… - PloS one, 2014 - journals.plos.org
To determine if patients with myasthenia gravis (MG) have antibodies to agrin, a
proteoglycan released by motor neurons and is critical for neuromuscular junction (NMJ) …

A comprehensive analysis of the epidemiology and clinical characteristics of anti-LRP4 in myasthenia gravis

P Zisimopoulou, P Evangelakou, J Tzartos… - Journal of …, 2014 - Elsevier
Double-seronegative myasthenia gravis (dSN-MG, without detectable AChR and MuSK
antibodies) presents a serious gap in MG diagnosis and understanding. Recently …

Autoantibodies to low‐density lipoprotein receptor–related protein 4 in myasthenia gravis

O Higuchi, J Hamuro, M Motomura… - Annals of …, 2011 - Wiley Online Library
Myasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction, where
acetylcholine receptor (AChR), muscle‐specific kinase (MuSK), and low‐density lipoprotein …

Anti-agrin autoantibodies in myasthenia gravis

C Gasperi, A Melms, B Schoser, Y Zhang, J Meltoranta… - Neurology, 2014 - AAN Enterprises
Objective: Because the extracellular matrix protein agrin is essential for neuromuscular
junction formation and maintenance, we tested the hypothesis that autoantibodies against …

Clinical features of LRP4/agrin‐antibody–positive myasthenia gravis: A multicenter study

MH Rivner, BM Quarles, JX Pan, Z Yu… - Muscle & …, 2020 - Wiley Online Library
Introduction Our aim in this study was to identify the prevalence and clinical characteristics of
LRP4/agrin‐antibody–positive double‐seronegative myasthenia gravis (DNMG). Methods …

LRP 4 antibodies in serum and CSF from amyotrophic lateral sclerosis patients

JS Tzartos, P Zisimopoulou, M Rentzos… - Annals of clinical …, 2014 - Wiley Online Library
Objective Amyotrophic lateral sclerosis (ALS) and myasthenia gravis (MG) are caused,
respectively, by motor neuron degeneration and neuromuscular junction (NMJ) dysfunction …

Clinical features and diagnostic usefulness of antibodies to clustered acetylcholine receptors in the diagnosis of seronegative myasthenia gravis

PMR Cruz, M Al-Hajjar, S Huda, L Jacobson… - JAMA …, 2015 - jamanetwork.com
Importance Cell-based assays (CBAs) were shown to improve detection of acetylcholine
receptor (AChR) antibodies in patients with myasthenia gravis (MG). Herein, we asked …