Hepatocellular carcinoma (HCC) is the fifth most common malignant tumor worldwide, and is
the third most common cause of cancer related death. Constitutive activation of NF-κB is the …

TNF is a pleotropic cytokine known to be involved in the progression of several pro-
inflammatory disorders. Many therapeutic agents have been designed to counteract the …

Aberrant activation of NF-κB is linked with the progression of human malignancies including
hepatocellular carcinoma (HCC), and blockade of NF-κB signaling could be a potential …

Background: Inflammation substantially contributes to the development and progression of
malignancies. cancer-related inflammation, has been proposed to promote tumor …

Coumarins possesses immeasurable antitumor potential with minimum side effects
depending on the substitutions on the basic nucleus, which exhibits great prospects for …

In a previous work of ours dehydroxymethyl-epoxyquinomicin (DHMEQ), an inhibitor of NF-
κB, was shown to induce apoptosis through Reactive Oxygen Species (ROS) production in …

Hepatocellular carcinoma (HCC) is a fatal disease and ranked fifth in cancer related
mortality. Persistent activation of NF-κB is responsible for the oncogenesis, metastasis …

Glycycoumarin (GCM) is a major bioactive coumarin compound isolated from licorice and
the anti-cancer activity of GCM has not been scientifically addressed. In the present study …

The discovery of new uses for older, clinically approved drugs is one way to expedite drug
development for cancer. Thiocolchicoside, a semisynthetic colchicoside from the plant …

Background The transcription factor nuclear factor-κB (NF-κB) is constitutively activated in a
variety of human cancers, including gastric cancer. NF-κB inhibitors that selectively kill …