Prostate epithelial basal cells are highly plastic in their luminal differentiation capability.
Basal stem cells actively produce luminal cells during organogenesis, but become restricted …

Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the
identity and lineage potential of stem cells within human tissues. By combining quantitative …

The prostate epithelium is composed of two predominant cell populations: luminal and basal
epithelial cells. Luminal cells have a secretory function that supports male fertility while …

Prevailing theories suggest that luminal cells are the origin of prostate cancer because it is
histologically defined by basal cell loss and malignant luminal cell expansion. We …

Background Signals between stem cells and stroma are important in establishing the stem
cell niche. However, very little is known about the regulation of any mammalian stem cell …

Many glandular epithelia are mainly composed of basal cells and luminal cells, including the
prostate gland. Adult prostate basal and luminal cells are independently self-sustained by …

Contact with the extracellular matrix is essential for maintenance of epithelial cells in many
tissues, while in its absence epithelial cells can detach and undergo anoikis. Here, we show …

Normal prostatic epithelium is composed of basal and luminal cells. Prostate cancer can be
initiated in both benign basal and luminal stem cells, but because basal cell markers are not …

The prostate is formed by a branched glandular epithelium composed of basal cells (BCs)
and luminal cells (LCs). Multipotent and unipotent stem cells (SCs) mediate the initial steps …

The isolation and characterization of prostatic stem cells has received significant attention in
the last few years based on the belief that aberrant regulation of adult stem cells leads to …