Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

P Lenormand, C Sardet, G Pages… - The Journal of cell …, 1993 - rupress.org
Mitogen-activated protein kinases (p42mapk and p44mapk) are serine/threonine kinases
that are activated rapidly in cells stimulated with various extracellular signals. This activation …

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

G Pages, P Lenormand, G L'Allemain… - Proceedings of the …, 1993 - National Acad Sciences
The mitogen-activated protein kinases (MAP kinases) p42mapk and p44mapk are
serine/threonine kinases rapidly activated in cells stimulated with various extracellular …

[HTML][HTML] Signal transduction within the nucleus by mitogen-activated protein kinase.

A Seth, FA Gonzalez, S Gupta, DL Raden… - Journal of Biological …, 1992 - Elsevier
The nucleus is an important target of signal transduction by growth factor receptors that
stimulate mitogen-activated protein (MAP) kinases. We tested the hypothesis that MAP …

[HTML][HTML] Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry

A Brunet, D Roux, P Lenormand, S Dowd… - The EMBO …, 1999 - embopress.org
Mitogen‐activated protein kinase (MAPK) modules, composed of three protein kinases
activated by successive phosphorylation, are involved in the signal transduction of a wide …

Mitogen-activated protein kinase kinase activity is required for the G2/M transition of the cell cycle in mammalian fibroblasts

JH Wright, E Munar, DR Jameson… - Proceedings of the …, 1999 - National Acad Sciences
The mitogen-activated protein kinase (MAPK) cascade is required for mitogenesis in somatic
mammalian cells and is activated by a wide variety of oncogenic stimuli. Specific roles for …

Cell cycle reentry of mammalian fibroblasts is accompanied by the sustained activation of P44mapk and P42mapk isoforms in the G1 phase and their inactivation at …

S Meloche - Journal of cellular physiology, 1995 - Wiley Online Library
Mitogen‐activated protein (MAP) kinases are serine/threonine kinases that are rapidly
activated in response to mitogenic stimuli. Here we examined the enzymatic activity and …

Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1).

G Pages, A Brunet, G L'Allemain, J Pouyssegur - The EMBO journal, 1994 - embopress.org
In response to various external stimuli, MAP kinases are activated by phosphorylation on
tyrosine and threonine by MAP kinase kinase (MAPKK), a dual specificity kinase. This …

Constitutive MAP kinase phosphatase (MKP-1) expression blocks G1 specific gene transcription and S-phase entry in fibroblasts.

JM Brondello, FR McKenzie, H Sun, NK Tonks… - Oncogene, 1995 - europepmc.org
MAP kinase (mitogen activated protein kinase) represents a ubiquitously expressed family of
kinases whose long term activation via phosphorylation is essential for the mitogenic …

Identification and characterization of a new mammalian mitogen-activated protein kinase kinase, MKK2

J Wu, JK Harrison, P Dent, KR Lynch… - … and cellular biology, 1993 - Taylor & Francis
Mitogen-activated protein (MAP) kinases are serine/threonine protein kinases activated by
dual phosphorylation on threonine and tyrosine residues. A MAP kinase kinase (MKK1 or …

Functional expression and growth factor activation of an epitope-tagged p44 mitogen-activated protein kinase, p44mapk.

S Meloche, G Pages, J Pouyssegur - Molecular biology of the cell, 1992 - Am Soc Cell Biol
Mitogen-activated protein kinases (MAPKs) or extracellular signal-regulated kinases (ERKs)
are serine/threonine kinases of apparent Mr 42-44 kDa that are rapidly activated by a variety …