Mitochondrial nitric oxide synthase: a ubiquitous regulator of oxidative phosphorylation?

TE Bates, A Loesch, G Burnstock, JB Clark - Biochemical and biophysical …, 1996 - Elsevier
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in mitochondria isolated from heart, skeletal muscle, and kidney, using a monoclonal …

Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver

TE Bates, A Loesch, G Burnstock, JB Clark - Biochemical and biophysical …, 1995 - Elsevier
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase
in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal …

[HTML][HTML] Biochemistry of mitochondrial nitric-oxide synthase

SL Elfering, TM Sarkela, C Giulivi - Journal of Biological Chemistry, 2002 - ASBMB
We reported that the generation of nitric oxide by mitochondria is catalyzed by a constitutive,
mitochondrial nitric-oxide synthase (mtNOS). Given that this production may establish the …

Mitochondrial nitric‐oxide synthase: role in pathophysiology

V Haynes, S Elfering, R Squires, N Traaseth… - IUBMB …, 2003 - Wiley Online Library
The biochemistry of the mitochondrial production of nitric oxide is reviewed to gain insight
into the basic role of this radical in mitochondrial and cellular oxidative metabolism. The …

Characterization and function of mitochondrial nitric-oxide synthase

C Giulivi - Free Radical Biology and Medicine, 2003 - Elsevier
The mitochondrial production of nitric oxide is catalyzed by a nitric-oxide synthase. This
enzyme has the same cofactor and substrate requirements as other constitutive nitric-oxide …

Mitochondrial nitric oxide synthase is constitutively active and is functionally upregulated in hypoxia

Z Lacza, M Puskar, JP Figueroa, J Zhang… - Free Radical Biology …, 2001 - Elsevier
Nitric oxide is a potent modulator of mitochondrial respiration, ATP synthesis, and KATP
channel activity. Recent studies show the presence of a potentionally new isoform of the …

Oxygen dependence of mitochondrial nitric oxide synthase activity

S Alvarez, LB Valdez, T Zaobornyj, A Boveris - … and biophysical research …, 2003 - Elsevier
The effect of O2 concentration on mitochondrial nitric oxide synthase (mtNOS) activity and
on O2− production was determined in rat liver, brain, and kidney submitochondrial …

[HTML][HTML] Purification and characterization of a nitric-oxide synthase from rat liver mitochondria

A Tatoyan, C Giulivi - Journal of Biological Chemistry, 1998 - ASBMB
The biosynthesis of nitric oxide (NO⋅) in different cell types occurs concomitantly with the
conversion ofl-arginine to l-citrulline by the enzyme nitric-oxide synthase (NOS). NO⋅ has …

[HTML][HTML] Nitric oxide synthase activity in mitochondria

P Ghafourifar, C Richter - FEBS letters, 1997 - Elsevier
In the present study we show the existence of a functional nitric oxide synthase (NOS) in rat
liver mitochondria. The enzyme uses l-arginine (l-arg) to produce nitric oxide (NO) and l …

[引用][C] Pharmacological regulation of mitochondrial nitric oxide synthase

A Boveris, SL Arnaiz, J Bustamante, S Alvarez… - Methods in …, 2002 - Elsevier
The production of nitric oxide (NO) was originally described by Ghafourifar and Richter 1
and by Giulivi et al. 2 in rat liver mitochondria. Later, NO production was reported in brain, 3 …