Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-
reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network …

Cardiomyocyte loss is the main cause of myocardial dysfunction following an ischemia-
reperfusion (IR) injury. Mitochondrial dysfunction and altered mitochondrial network …

Objective Matrix metalloproteinase‐2 (MMP‐2) is a ubiquitous protease that cleaves several
extracellular and intracellular proteins. MMP‐2 is activated intracellularly in response to …

During myocardial ischemia and reperfusion (IR) injury matrix metalloproteinase-2 (MMP-2)
is rapidly activated in response to oxidative stress. MMP-2 is a multifunctional protease that …

In the heart, autophagy has been implicated in cardioprotection and ischemia-reperfusion
tolerance, and the dysregulation of autophagy is associated with the development of heart …

Rationale: Both cardiomyocyte-restricted proteasome functional enhancement and
pharmacological proteasome inhibition (PSMI) were shown to attenuate myocardial …

Heart is a multi-cellular organ made up of various cell types interacting with each other.
Cardiomyocytes may benefit or suffer from crosstalk with noncardiomyocytes in response to …

Molecular studies examining the impact of mitochondrial morphology on the mammalian
heart have previously focused on dynamin related protein-1 (Drp-1) and mitofusin-2 (Mfn-2) …

Background Mitochondrial dynamics play a critical role in mitochondrial function. The
mitofusin 2 (MFN2) gene encodes a mitochondrial membrane protein that participates in …

Dysfunctions of the mitochondria and the ubiquitin–proteasome system, as well as
generation of reactive oxygen species (ROS), are linked to many aging-related …