Background C3 glomerulopathy (C3G) is characterized by the alternative-pathway (AP)
hyperactivation induced by nephritic factors or complement gene mutations. Mice deficient in …

C3 glomerulopathy refers to renal disorders characterized by abnormal accumulation of C3
within the kidney, commonly along the glomerular basement membrane (GBM). C3 …

C3 glomerulopathy is a complement-mediated renal disease that is frequently associated
with abnormalities in regulation of the complement alternative pathway. Mice with deficiency …

C3 glomerulopathy is a potentially life-threatening disease of the kidney caused by
dysregulated alternative pathway complement activation. The specific complement mediator …

Background: C3 glomerulopathy (C3G) is an ultra-rare kidney disease defined by underlying
complement dysregulation and characterized by complement C3 deposition on kidney …

Chronic serum sickness leads to the formation of glomerular immune complexes; however,
C57BL/6 mice do not develop glomerulonephritis unless complement factor H (CFH) is …

Introduction C3 glomerulopathies (C3G) are ultra-rare complement-mediated diseases that
lead to end-stage renal disease (ESRD) within 10 years of diagnosis in~ 50% of patients …

Background C3 glomerulopathy (C3G) is associated with dysregulation of the alternative
pathway of complement activation, and treatment options for C3G remain limited …

Background C3 glomerulopathy (C3G) is a life-threatening kidney disease caused by
dysregulation of the alternative pathway of complement (AP) activation. No approved …