Listeria monocytogenes is a Gram-positive bacterium which grows in the cytoplasm of
eukaryotic cells and can cause severe disease in immunocompromised individuals1, 2. In …

Class I major histocompatibility complex (MHC)-restricted CD8+ T cells have been
demonstrated to be effective mediators of both acquired and adoptive immunity to the …

Murine infection with the intracellular bacterium Listeria monocytogenes elicits MHC class I-
restricted CTL with specificity for multiple bacterial peptides. The variety and relative …

Protective immunity to infection by intracellular pathogens begins with expansion of Ag-
specific, effector T lymphocytes and is followed by persistence of pathogen-specific memory …

Listeria monocytogenes (L. monocytogenes) secretes proteins associated with its virulence
into the cytosol of infected cells. These secreted proteins are degraded by host cell …

Polymorphism of MHC class Ia molecules severely constrains vaccine development against
intracellular pathogens. Antigen presentation by MHC class Ib molecules, which are …

Unlike conventional CD8+ T cells, major histocompatibility complex (MHC) class Ib–
restricted CD8+ T cells show an activated phenotype in uninfected mice and respond rapidly …

We report evidence that a major histocompatibility complex-encoded nonclassic class I
molecule presents a foreign peptide to cytotoxic T lymphocytes (CTL) during an infection …

The ability of Listeria monocytogenes to gain access to the cytoplasm of infected cells results
in the processing and presentation of bacterial Ags through the MHC class I pathway. As a …

Listeria monocytogenes is an intracellular pathogen that enters the cytoplasm of infected
cells by secreting listeriolysin (LLO), a protein that destroys the phagosomal membrane. In …