The development of a scalable framework for biodesign automation is a formidable
challenge given the expected increase in part availability and the ever-growing complexity …

Through principled engineering methods, synthetic biology aims to build specialized
biological components that can be modularly composed to create complex systems. This …

The rational design of synthetic gene circuits has led to many successful applications over
the past decade. However, increasingly complex constructs also revealed that analogies to …

Our current ability to engineer biological circuits is hindered by design cycles that are costly
in terms of time and money, with constructs failing to operate as desired, or evolving away …

An integral challenge in synthetic circuit design is the selection of optimal parts to populate a
given circuit topology, so that the resulting circuit behavior best approximates the desired …

Synthetic biology promises to usher in a new era of scientific innovation and discovery [1].
Applicationsof thistechnology are broad and diverse [2]. Although applications frequently …

Synthetic biology is an emerging field in which biologists modify or design the behavior of
organisms to engineer systems that perform computation in diverse biological applications …

Synthetic biology is revolutionizing how we conceptualize and approach the engineering of
biological systems. Recent advances in the field are allowing us to expand beyond the …

Synthetic biology has been significantly shaped by modular design principles through
analogies to electrical and computer engineering. Although convenient, these parallels often …

Genetic design automation methods for combinational circuits often rely on standard
algorithms from electronic design automation in their circuit synthesis and technology …