Apigenin attenuates molecular, biochemical, and histopathological changes associated with renal impairments induced by gentamicin exposure in rats

MM Hussein, HA Althagafi, F Alharthi… - … Science and Pollution …, 2022 - Springer
Gentamicin (GM) is an aminoglycoside antibiotic used to treat bacterial infections. However,
its application is accompanied by renal impairments. Apigenin is a flavonoid found in many …

[HTML][HTML] Arbutin attenuates nephrotoxicity induced by gentamicin

E Emadi, M Pouramir, M Ghasemi-Kasman… - Avicenna Journal of …, 2021 - ncbi.nlm.nih.gov
Objective: In this study, the impact of arbutin was examined in a gentamicin (GM)-induced
nephrotoxicity model. Materials and Methods: Forty adult male Wistar rats were randomly …

Candesartan and epigallocatechin‐3‐gallate ameliorate gentamicin‐induced renal damage in rats through p38‐MAPK and NF‐κB pathways

HI Ahmed, EA Mohamed - Journal of biochemical and …, 2019 - Wiley Online Library
This study pointed to estimate the possible protective impacts of candesartan and/or
epigallocatechin‐3‐gallate (EGCG) against gentamicin‐induced nephrotoxicity. The current …

Ameliorative effect of berberine against gentamicin-induced nephrotoxicity in rats via attenuation of oxidative stress, inflammation, apoptosis and mitochondrial …

M Adil, AD Kandhare, G Dalvi, P Ghosh, S Venkata… - Renal failure, 2016 - Taylor & Francis
Background: Gentamicin (GM) is the commonly used antibiotics against Gram-negative
infection, but the nephrotoxic potential of drug limit its clinical interest. The aim of this study …

Protective effect of naringenin against gentamicin-induced nephrotoxicity in rats

AA Fouad, WH Albuali, A Zahran, W Gomaa - … toxicology and pharmacology, 2014 - Elsevier
The protective effect of naringenin, a flavonoid compound isolated from citrus fruits, was
investigated against nephrotoxicity induced by gentamicin (80 mg kg− 1/day, ip, for eight …

Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways

EHM Hassanein, FEM Ali, MR Kozman… - … Science and Pollution …, 2021 - Springer
Nephrotoxicity is the most common adverse effect of gentamicin (GNT). This study aimed to
investigate the possible nephroprotective effect of umbelliferone (UMB), against GNT …

[HTML][HTML] Irbesartan attenuates gentamicin-induced nephrotoxicity in rats through modulation of oxidative stress and endogenous antioxidant capacity

HM Al-Kuraishy, AI Al-Gareeb… - International journal of …, 2020 - journals.lww.com
Background: Overproduction of reactive oxygen species and free radicals is the main
mechanism beyond gentamicin-induced nephrotoxicity. Irbesartan and other angiotensin II …

Gentisic acid mitigates gentamicin-induced nephrotoxicity in rats

M Saeedavi, M Goudarzi, I Fatemi, Z Basir, SMA Noori… - Tissue and Cell, 2023 - Elsevier
The current investigation was considered to evaluate the beneficial effects of gentisic acid
(GA) on gentamicin (GEN)-induced nephrotoxicity in rat kidneys through assessment of …

Agmatine improves renal function in gentamicin-induced nephrotoxicity in rats

DH El-Kashef, AE El-Kenawi, MA Rahim… - Canadian Journal of …, 2016 - cdnsciencepub.com
The present study was designed to explore the possible protective effects of agmatine, a
known nitric oxide (NO) synthase inhibitor, against gentamicin-induced nephrotoxicity in …

[PDF][PDF] Oral administration of naringenin and a mixture of coconut water and Arabic gum attenuate oxidative stress and lipid peroxidation in gentamicin-induced …

HA Al-Amer, NS Al-Sowayan… - European Review for …, 2023 - europeanreview.org
OBJECTIVE: This study aimed to investigate the effect of oral administration of naringenin in
combination with an aqueous mixture of coconut water (CW) and Arabic gum (AG) on renal …