With the advent of dense maps of human genetic variation, it is now possible to detect
positive natural selection across the human genome. Here we report an analysis of over 3 …

We describe the Phase II HapMap, which characterizes over 3.1 million human single
nucleotide polymorphisms (SNPs) genotyped in 270 individuals from four geographically …

The human genome contains hundreds of regions whose patterns of genetic variation
indicate recent positive natural selection, yet for most the underlying gene and the …

Inherited genetic variation has a critical but as yet largely uncharacterized role in human
disease. Here we report a public database of common variation in the human genome: more …

Comparisons of DNA polymorphism within species to divergence between species enables
the discovery of molecular adaptation in evolutionarily constrained genes as well as the …

Genome-wide patterns of variation across individuals provide a powerful source of data for
uncovering the history of migration, range expansion, and adaptation of the human species …

The considerable range of observed phenotypic variation in human populations may reflect,
in part, distinctive processes of natural selection and adaptation to variable environmental …

The ability to detect recent natural selection in the human population would have profound
implications for the study of human history and for medicine. Here, we introduce a framework …

Natural selection is a significant force that shapes the architecture of the human genome
and introduces diversity across global populations. The question of whether advantageous …

Positive natural selection is the force that drives the increase in prevalence of advantageous
traits, and it has played a central role in our development as a species. Until recently, the …