Mice transgenic for antisense Notch and normal mice treated with inhibitors of the Notch-
activating enzyme γ-secretase showed reduced damage to brain cells and improved …

Notch-1 (Notch) is a cell surface receptor that regulates cell-fate decisions in the developing
nervous system, and it may also have roles in synaptic plasticity in the adult brain. Binding of …

Stroke is the world's second leading cause of mortality, with a high incidence of morbidity.
Numerous neuronal membrane receptors are activated by endogenous ligands and may …

Notch signaling is critically involved in various biological events. Notch undergoes cleavage
by the γ-secretase enzyme to release Notch intracellular domain that will translocate into …

Background and Purpose—Activation of Notch worsens ischemic brain damage as
antisense knockdown or pharmacological inhibition of the Notch pathway reduces the infarct …

Signalling through the receptor protein Notch, which is involved in crucial cell-fate decisions
during development, requires ligand-induced cleavage of Notch. This cleavage occurs …

Cleavage of the amyloid precursor protein (APP) by γ-secretase generates a neurotoxic
amyloid β-peptide (Aβ) that is thought to be associated with the neurodegeneration …

Dysregulated Notch signaling has been implicated in numerous human diseases, including
a broad spectrum of cancers. Mutations in Notch1 are prevalent in T-cell acute lymphoblastic …

Background and Purpose—The formation of reactive astrocytes is common after central
nervous system injuries such as stroke. However, the signaling pathway (s) that control …

Notch is an integral membrane protein that functions as receptor for ligands such as jagged
and delta that are associated with the surface of neighboring cells. Upon ligand binding …