SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate
D Olagnier, E Farahani, J Thyrsted… - Nature …, 2020 - nature.com
Antiviral strategies to inhibit Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …
CoV2) and the pathogenic consequences of COVID-19 are urgently required. Here, we …
SARS-CoV-2 inhibits NRF2-mediated antioxidant responses in airway epithelial cells and in the lung of a murine model of infection
Several viruses have been shown to modulate the transcription factor nuclear factor
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
erythroid 2-related factor 2 (NRF2), the master regulator of redox homeostasis. The severe …
Potential role of antioxidant and anti-inflammatory therapies to prevent severe SARS-Cov-2 complications
AM Fratta Pasini, C Stranieri, L Cominacini, C Mozzini - Antioxidants, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic is caused by a novel severe acute
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2). Here, we review the …
Nrf2 Activator PB125® as a Potential Therapeutic Agent against COVID-19
JM McCord, BM Hybertson, A Cota-Gomez, KP Geraci… - Antioxidants, 2020 - mdpi.com
Nrf2 is a transcription factor that regulates cellular redox balance and the expression of a
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
wide array of genes involved in immunity and inflammation, including antiviral actions. Nrf2 …
Can activation of NRF2 be a strategy against COVID-19?
A Cuadrado, M Pajares, C Benito… - Trends in …, 2020 - cell.com
Acute respiratory distress syndrome (ARDS) caused by SARS-CoV-2 is largely the result of
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …
a dysregulated host response, followed by damage to alveolar cells and lung fibrosis …
SARS-CoV-2 virus NSP14 Impairs NRF2/HMOX1 activation by targeting Sirtuin 1
Most deaths from the COVID-19 pandemic are due to acute respiratory distress syndrome
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …
(ARDS)-related respiratory failure. Cytokine storms and oxidative stress are the major …
[HTML][HTML] The FDA-approved gold drug auranofin inhibits novel coronavirus (SARS-COV-2) replication and attenuates inflammation in human cells
SARS-COV-2 has recently emerged as a new public health threat. Herein, we report that the
FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro …
FDA-approved drug, auranofin, inhibits SARS-COV-2 replication in human cells at low micro …
Anti-viral potential and modulation of Nrf2 by curcumin: pharmacological implications
Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential transcription factor that
maintains the cell's redox balance state and reduces inflammation in different adverse …
maintains the cell's redox balance state and reduces inflammation in different adverse …
SARS-CoV-2 nonstructural protein 1 inhibits the interferon response by causing depletion of key host signaling factors
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have …
the ongoing coronavirus disease 2019 (COVID-19) pandemic. While previous studies have …
Strategies for targeting sars cov-2: Small molecule inhibitors—The current status
NM Beeraka, SP Sadhu… - Frontiers in …, 2020 - frontiersin.org
Severe Acute Respiratory Syndrome-Corona Virus-2 (SARS-CoV-2) induced Coronavirus
Disease-19 (COVID-19) cases have been increasing at an alarming rate (7.4 million positive …
Disease-19 (COVID-19) cases have been increasing at an alarming rate (7.4 million positive …
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