The phosphoinositide 3-kinase/mammalian target of rapamycin/protein kinase B
(PI3K/mTOR/Akt) signaling pathway is central to a plethora of cellular mechanisms in a wide …

Highlights•Preclinical studies support us of PI3K inhibitors in autoimmunity and
inflammation.•First in class PI3K inhibitor has been approved for treatment of B cell …

The phosphoinositide 3‐kinase (PI3K) family of lipid kinases regulates diverse aspects of
lymphocyte behavior. This review discusses how genetic and pharmacological tools have …

Over the past two decades, new insights have positioned phosphoinositide 3-kinase-γ
(PI3Kγ) as a context-dependent modulator of immunity and inflammation. Recent advances …

Activation of PI3K (phosphoinositide 3-kinase) is a shared response to engagement of
diverse types of transmembrane receptors. Depending on the cell type and stimulus, PI3K …

Highlights•The γ and δ isoforms of PI3K have important non-redundant roles in multiple cells
of the immune system.•Evidence for a role of PI3K in autoimmune pathology.•The impact of …

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

In the past decade, the availability of genetically modified animals has enabled the
discovery of interesting roles for phosphatidylinositol 3‐kinase‐γ (PI3Kγ) and‐δ (PI3Kδ) in …

Phosphoinositol 3-kinases (PI3Ks) γ and δ are key enzymes in hematopoietic cells and have
been seen as high-value targets for the treatment of diseases with inflammatory and …

Dysregulated signal transduction in innate and adaptive immune cells is known to be
associated with the development of various autoimmune and inflammatory diseases …