A splice variant of the human ion channel TRPM2 modulates neuroblastoma tumor growth through hypoxia-inducible factor (HIF)-1/2α
S Chen, NE Hoffman, S Shanmughapriya, L Bao… - Journal of Biological …, 2014 - ASBMB
The calcium-permeable ion channel TRPM2 is highly expressed in a number of cancers. In
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …
neuroblastoma, full-length TRPM2 (TRPM2-L) protected cells from moderate oxidative stress …
Depletion of the human ion channel TRPM2 in neuroblastoma demonstrates its key role in cell survival through modulation of mitochondrial reactive oxygen species …
L Bao, S Chen, K Conrad, K Keefer, T Abraham… - Journal of Biological …, 2016 - ASBMB
Transient receptor potential melastatin 2 (TRPM2) ion channel has an essential function in
modulating cell survival following oxidant injury and is highly expressed in many cancers …
modulating cell survival following oxidant injury and is highly expressed in many cancers …
Role of TRPM2 in cell proliferation and susceptibility to oxidative stress
S Chen, W Zhang, Q Tong, K Conrad… - … of Physiology-Cell …, 2013 - journals.physiology.org
The transient receptor potential (TRP) channel TRPM2 is an ion channel that modulates cell
survival. We report here that full-length (TRPM2-L) and short (TRPM2-S) isoform expression …
survival. We report here that full-length (TRPM2-L) and short (TRPM2-S) isoform expression …
TRPM2 in Cancer
BA Miller - Cell Calcium, 2019 - Elsevier
The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …
viability of a number of cell types after oxidative stress. It is highly expressed in many …
The human ion channel TRPM2 modulates neuroblastoma cell survival and mitochondrial function through Pyk2, CREB, and MCU activation
I Hirschler-Laszkiewicz, S Chen… - … of Physiology-Cell …, 2018 - journals.physiology.org
Transient receptor potential melastatin channel subfamily member 2 (TRPM2) has an
essential function in cell survival and is highly expressed in many cancers. Inhibition of …
essential function in cell survival and is highly expressed in many cancers. Inhibition of …
Increasing the TRPM2 channel expression in human neuroblastoma SH-SY5Y cells augments the susceptibility to ROS-induced cell death
X An, Z Fu, C Mai, W Wang, L Wei, D Li, C Li, LH Jiang - Cells, 2019 - mdpi.com
Human neuroblastoma SH-SY5Y cells are a widely-used human neuronal cell model in the
study of neurodegeneration. A recent study shows that, 1-methyl-4-phenylpyridine ion …
study of neurodegeneration. A recent study shows that, 1-methyl-4-phenylpyridine ion …
Role of TRPM2 in brain tumours and potential as a drug target
D Ji, Z Luo, A Ovcjak, R Alanazi, MH Bao… - Acta Pharmacologica …, 2022 - nature.com
Ion channels are ubiquitously expressed in almost all living cells, and are the third-largest
category of drug targets, following enzymes and receptors. The transient receptor potential …
category of drug targets, following enzymes and receptors. The transient receptor potential …
The oncogenic roles of TRPM ion channels in cancer
KK Wong, AH Banham, NS Yaacob… - Journal of Cellular …, 2019 - Wiley Online Library
Transient receptor potential (TRP) proteins are a diverse family of ion channels present in
multiple types of tissues. They function as gatekeepers for responses to sensory stimuli …
multiple types of tissues. They function as gatekeepers for responses to sensory stimuli …
Roles of TRPM8 ion channels in cancer: proliferation, survival, and invasion
NS Yee - Cancers, 2015 - mdpi.com
The goal of this article is to provide a critical review of the transient receptor potential
melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular …
melastatin-subfamily member 8 (TRPM8) in cancers, with an emphasis on its roles in cellular …
Identification of the role of TRPM8 in glioblastoma and its effect on proliferation, apoptosis and invasion of the U251 human glioblastoma cell line
J Zeng, Y Wu, S Zhuang, L Qin, S Hua… - Oncology …, 2019 - spandidos-publications.com
Glioblastoma multiforme (GBM) is the most commonly occurring brain cancer, and is
characterized by its poor patient outcomes. The present study examined the mRNA …
characterized by its poor patient outcomes. The present study examined the mRNA …