To understand the hapten–protein complex formation in the context of skin contact allergy to
p-amino aromatic derivatives, 2, 5-dimethyl-p-benzoquinonediimine was used as a model …

Exposure to the skin sensitizer p-phenylenediamine (PPD) is associated with allergic
contact dermatitis; however, the ability of PPD to modify protein has not been fully …

2, 5-[13C]-Dimethyl-p-benzoquinonediimine was synthesized, and its reactivity toward
several nucleophilic amino acids was studied by associated 13C and 1H {13C} NMR …

The molecular basis of chemical allergy is rooted in the ability of an allergen (hapten) to
modify endogenous proteins. This mechanistic understanding aided development of …

2, 5-Dimethyl-p-benzoquinonediimine was used as a model to study the reactivity of p-
benzoquinonediimines, the first oxidation intermediates of allergenic p-amino aromatic …

Skin sensitizers chemically modify skin proteins rendering them immunogenic. Sensitizing
chemicals have been divided into applicability domains according to their suspected …

RATIONALE para‐Phenylenediamine (PPD) is a potent and well‐known allergen, which is
commonly used in hair or fur dyes and can cause severe allergic contact dermatitis. In this …

A key step in the skin sensitization process is the formation of a covalent adduct between
skin sensitizers and endogenous proteins and/or peptides in the skin. Based on this …

Haptens causing type I allergy have been shown to predominantly form lysine adducts in the
carrier protein, while many haptens giving rise to type IV allergy preferentially form adducts …

A large proportion of allergic skin reactions are considered to be the result of skin exposure
to small organic chemicals that possess the intrinsic ability to covalently modify skin proteins …