Excision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylation
H Hashimoto, S Hong, AS Bhagwat… - Nucleic acids …, 2012 - academic.oup.com
The mammalian thymine DNA glycosylase (TDG) is implicated in active DNA demethylation
via the base excision repair pathway. TDG excises the mismatched base from G: X …
via the base excision repair pathway. TDG excises the mismatched base from G: X …
Structural basis of damage recognition by thymine DNA glycosylase: Key roles for N-terminal residues
CT Coey, SS Malik, LS Pidugu, KM Varney… - Nucleic acids …, 2016 - academic.oup.com
Abstract Thymine DNA Glycosylase (TDG) is a base excision repair enzyme functioning in
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …
DNA repair and epigenetic regulation. TDG removes thymine from mutagenic G· T mispairs …
Structural basis for excision of 5-formylcytosine by thymine DNA glycosylase
LS Pidugu, JW Flowers, CT Coey, E Pozharski… - Biochemistry, 2016 - ACS Publications
Thymine DNA glycosylase (TDG) is a base excision repair enzyme with key functions in
epigenetic regulation. Performing a critical step in a pathway for active DNA demethylation …
epigenetic regulation. Performing a critical step in a pathway for active DNA demethylation …
Lesion processing by a repair enzyme is severely curtailed by residues needed to prevent aberrant activity on undamaged DNA
DNA base excision repair is essential for maintaining genomic integrity and for active DNA
demethylation, a central element of epigenetic regulation. A key player is thymine DNA …
demethylation, a central element of epigenetic regulation. A key player is thymine DNA …
[HTML][HTML] Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
S Cortellino, J Xu, M Sannai, R Moore, E Caretti… - Cell, 2011 - cell.com
DNA methylation is a major epigenetic mechanism for gene silencing. Whereas
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
methyltransferases mediate cytosine methylation, it is less clear how unmethylated regions …
Thymine DNA glycosylase can rapidly excise 5-formylcytosine and 5-carboxylcytosine: potential implications for active demethylation of CpG sites
Thymine DNA glycosylase (TDG) excises T from G· T mispairs and is thought to initiate base
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …
excision repair (BER) of deaminated 5-methylcytosine (mC). Recent studies show that TDG …
Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair
While methylcytosines serve as the fifth base encoding epigenetic information, they are also
a dangerous endogenous mutagen due to their intrinsic instability. Methylcytosine …
a dangerous endogenous mutagen due to their intrinsic instability. Methylcytosine …
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA
Human thymine DNA glycosylase (hTDG) efficiently excises 5-carboxylcytosine (5caC), a
key oxidation product of 5-methylcytosine in genomic DNA, in a recently discovered cytosine …
key oxidation product of 5-methylcytosine in genomic DNA, in a recently discovered cytosine …
Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
H Hashimoto, X Zhang, X Cheng - Nucleic acids research, 2012 - academic.oup.com
The mammalian DNA glycosylase—methyl-CpG binding domain protein 4 (MBD4)—is
involved in active DNA demethylation via the base excision repair pathway. MBD4 contains …
involved in active DNA demethylation via the base excision repair pathway. MBD4 contains …
The role of thymine DNA glycosylase in transcription, active DNA demethylation, and cancer
Simple Summary Thymine DNA Glycosylase (TDG) is a DNA repair protein that plays an
important role in gene regulation. Recent studies have shown that TDG interacts with …
important role in gene regulation. Recent studies have shown that TDG interacts with …