Renal fibrosis is the histological manifestation of a progressive, usually irreversible process
causing chronic and end-stage kidney disease. We performed genome-wide transcriptome …

Renal proximal tubular cells are the most energy-demanding cells in the body. The ATP that
they use is mostly produced in their mitochondrial and peroxisomal compartments, by the …

The underlying cellular events driving kidney fibrogenesis and metabolic dysfunction are
incompletely understood. Here, we employed single-cell combinatorial indexing RNA …

Kidney fibrosis is the hallmark of chronic kidney disease progression; however, at present
no antifibrotic therapies exist,–. The origin, functional heterogeneity and regulation of scar …

Kidney fibrosis is marked by an epithelial-to-mesenchymal transition (EMT) of tubular
epithelial cells (TECs). Here we find that, during renal fibrosis, TECs acquire a partial EMT …

There are several causes of chronic kidney disease, but all of these patients have renal
fibrosis. Although many studies have examined the pathogenesis of renal fibrosis, there are …

The kidney has tremendous capacity to repair after acute injury, however, pathways guiding
adaptive and fibrotic repair are poorly understood. We developed a model of adaptive and …

Progressive kidney fibrosis contributes greatly to end-stage renal failure, and no specific
treatment is available to preserve organ function. During renal fibrosis, myofibroblasts …

Fibrosis, a characteristic of all chronic kidney diseases, is now recognized to be an
independent predictor of disease progression. Deposition of pathological matrix in the walls …

Kidneys are intricate three-dimensional structures in the body, yet the spatial and molecular
principles of kidney health and disease remain inadequately understood. We generated …