The small number of hematopoietic stem and progenitor cells in cord blood units limits their
widespread use in human transplant protocols. We identified a family of chemically related …

Haematopoietic stem cells (HSCs) are a rare cell type that reconstitute the entire blood and
immune systems after transplantation and can be used as a curative cell therapy for a variety …

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell
(HSC) transplants remains limited by the ability to expand these cells ex vivo. An unbiased …

An improved understanding of stem-cell and regenerative biology, as well as a better control
of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries …

Wagers et al.(1) investigated the possibility of marrow cell plasticity at the single cell level, as
we did (2). Although they found “little evidence for developmental plasticity”—ie, marrow …

Multiple sclerosis involves an aberrant autoimmune response and progressive failure of
remyelination in the central nervous system. Prevention of neural degeneration and …

Hematopoietic cells differentiate in steps marked by the acquisition or loss of specific
phenotypic characteristics. Human bone marrow cells that were responsive to the early …

Hematopoietic stem cells (HSCs) quiescently reside in bone marrow niches and have the
capacity to self-renew or differentiate to form all of the blood cells throughout the lifespan of …

Stem cells are proposed to segregate chromosomes asymmetrically during self-renewing
divisions so that older ('immortal') DNA strands are retained in daughter stem cells whereas …

Small molecules that modulate stem cell fate and function offer significant opportunities that
will allow the full realization of the therapeutic potential of stem cells. Rational design and …